Roles for microRNAs in conferring robustness to biological processes.

By Margaret S. Ebert, Phillip A. Sharp. Cell, 2012

1,593 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6b013c0d6e50892e624efe037a4c355dc9b3aa55

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In Cancer Research

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Citations in the corpus

Metazoan MicroRNAs (2018, background): “Indeed, as might be expected for transcription factors or any other component of these networks, deletion of miRNAs can reduce tolerance to environmental challenges, genetic perturbations, injury, or disease (Ebert and Sharp, 2012; Mendell and Olson, 2012; Cassidy et al., 2016; Kasper et al., 2017) ”
miRNet 2.0: network-based visual analytics for miRNA functional analysis and systems biology (2020, background): “It is important to keep in mind that miRNA functions are highly dependent on the context (abundance, location, cell type, cell state e tc. ) and the effects can be dynamic and transient to confer robustness to biological processes (60).”
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018, background): “A common indicator of expression noise control is high mRNA to protein ratios, rendering reduced translational rates resistant to random fluctuations in mRNA concentration (91), i.”
Network resilience (2020, background): “1, but also confer resilience to biological processes against intrinsic and extrinsic noise [362, 305].”
IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. (2014, background): “…are involved in the suppression of EMT by directly inhibiting the expression of the EMT-inducing transcription factor (EMT-TF) SNAIL (18, 19). miRNAs frequently form feedback loops, since they are themselves regulated by transcription factors, which they directly or indirectly target (20, 21).”
The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs (2013, background): “…of let-7 targets Dicer and Hmga2 decreased in response to increased let-7 function, a phenomenon that was not observed in proliferating HEK293 (Figure 4) or HUVEC (Supplemental Figure S1C, D) cells, consistent with context-dependent miRNA effects (Ebert and Sharp, 2012; Mukherji et al., 2011).”
Transcriptional Regulation and its Misregulation in Disease (2013, positive): “Many of the ncRNAs contribute to control of gene expression through modulation of transcriptional or post-transcriptional processes (Bartel, 2009; Ebert and Sharp, 2012; Lee, 2012; Orom and Shiekhattar, 2011; Rinn and Chang, 2012; Wright and Ciosk, 2012).”