The mesolimbic dopamine reward circuit in depression.

By E. Nestler, William A. Carlezon. Biological Psychiatry, 2006

2,080 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/af0b0e1edd9b53e1f61b6306af500049ba06fb62

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. E. Nestler
2. R. Duman
3. K. Tye
4. V. Krishnan
5. Karl Deisseroth
6. T. Rantamäki
7. G. Agam
8. R. Belmaker

In Cognitive Neuroscience

1. R. Duman
2. R. J. Dolan
3. A. Beck
4. G. Agam
5. R. Belmaker
6. Keith Bredemeier
7. E. Nestler
8. Peter S. Dayan

Citations in the corpus

• Neural mechanisms of the cognitive model of depression (2011, background): “In healthy individuals, the ability to experience and maintain positive affect is closely associated with brain systems that mediate reward and motivation, which include the nucleus accumben”
• Linking Molecules to Mood: New Insight Into the Biology of Depression (2010, positive): “neurotrophic and cytokine signaling cascades, ion channels, HDACs, circadian genes (87,107), transcription factors (e.”
• New approaches to antidepressant drug discovery: beyond monoamines (2006, background): “Although the site of the pathology is unknown, there is growing knowledge of the brain regions that might mediate the diverse symptoms of depressio”
• A computational and neural model of momentary subjective well-being (2014, result): “At the very least, this hints at a link between dopamine and emotional state, consistent with suggestions that this neuromodulator plays a role in mood regulation in healthy and depressed subjects (42).”
• Role of neurotrophic factors in depression. (2007, background): “The functional consequences of plasticity in hippocampal–prefrontal network and mesolimbic pathways produce opposite effects, as far as depression-related behavior is concerned [25] and, therefore, it is not surprising that increased BDNF levels and inhibition of TrkB signaling produce different eff”
• The molecular neurobiology of depression (2008, neutral): “, a striatal subregion that is important for reward and for hedonic deficits in depressio”
• Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms (2008, background): “The accumbens has a central role in the mechanisms of natural reward; as such, its dysregulation in depression is thought to relate to symptoms of anhedonia (Dunn et al, 2002; Nestler and Carlezon, 2006).”