FGF/FGFR signaling in health and disease

By Yangli Xie, N. Su, Jing Yang, Q. Tan, Shuo Huang, M. Jin, Z. Ni, Bin Zhang, Dali Zhang, F. Luo and 5 more. Signal Transduction and Targeted Therapy, 2020

748 citations recorded by the source corpus.

Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation, proliferation, and apoptosis of various types of cells. In this review, we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of diseases, which is a consequence of FGF signaling dysregulation, including cancers and chronic kidney disease (CKD). In this context, the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4bd8a9ac06fe2bc4d71c78fbcea5e19bc90c59bb

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In Molecular Biology

Citations in the corpus

Fibroblasts: origins, definitions, and functions in health and disease (2021, background): “Although many signaling factors can affect fibroblasts and contribute to fibrosis, such as FGFs (Xie et al., 2020), in this section, we review major roles of the PDGF pathway in fibroblast proliferation and self-renewal, TGF-b superfamily Cell 184, July 22, 2021 3857 pathways in fibroblast function,”