Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B

By R. V. Montfort, M. Congreve, D. Tisi, R. Carr, H. Jhoti. Nature, 2003

638 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b8fc47b6b119eda241427f7b0e4f8300bbfa3bd3

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Citations in the corpus

ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis (2007, background): “The -SOH is highly reactive, its stability being influenced by the availability of a proximal -SH with which it condenses to form a disulphide bond, or by availability of a proximal nitrogen to form a sulphenamide 115,116 or by the presence of H 2 O 2 , which further oxidizes it to form sulphinic (-”
Radical-free biology of oxidative stress. (2008, background): “In certain protein structures, they can be stabilized as sulfenamides (150, 185).”
Chemistry and biology of reactive oxygen species in signaling or stress responses (2011, background): “Sulfenic acids are reactive intermediates that can be trapped by internal thiols to form an intramolecular disulfide, react with glutathione (glutathionylation) or other external thiols to form intermolecular disulfide species or cyclize into sulfenamide structure”
Cadmium stress: an oxidative challenge (2010, positive): “Hyperoxidation of the sulphenic acid to sulphinic acid was thought to be an irreversible modification until the discovery of the sulphinic acid reductase sulfiredoxin was discovered (Biteau et al. 2003; Salmeen et al. 2003; van Montfort et al. 2003; Barranco-Medina et al. 2009).”
Redox redux: revisiting PTPs and the control of cell signaling. (2005, background): “…of the active site Cys to sulphenic acid, oxygen is rapidly eliminated to produce a cyclic sulphenamide, a 5-atom ring structure in which a covalent bond is formed between the Cys sulfur atom and the main chain nitrogen of the adjacent Ser residue (Salmeen et al., 2003; van Montfort et al., 2003).”
Signaling Functions of Reactive Oxygen Species (2010, background): “Thus, while it has been demonstrated that PTP1B can react in vitro with H2O2 to form a sulfenic acid that goes on to form a sulfenyl-amide intermediate (85, 86), this is rather unlikely to occur in a cell where it would be in competition with Prxs and Sec-GPxs, which are abundant in the cytosol and ”