Redox redux: revisiting PTPs and the control of cell signaling.

By N. Tonks. Cell, 2005

748 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f53a0453865d30e081c7c98751994ffac109dc24

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Citations in the corpus

Protein-tyrosine phosphatases and cancer (2006, background): “The improved understanding of the biochemistry of PTP oxidation (see Box 1 ; recently reviewed in Ref”
Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. (2014, background): “Oxidation of their Cys residues reversibly abolishes enzymatic activity (287).”
Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling (2018, neutral): “The active site of PTPs contains an essential cysteine residue that is in the thiolate anion form (Cys-S−) at neutral pH and is therefore highly susceptible to oxidation (Tonks, 2005; Rhee, 2006).”
Reconciling the chemistry and biology of reactive oxygen species. (2008, background): “While oxidation of these proteins has been observe”
ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis (2007, background): “Well-characterized targets of these endogenous ROS signals are the redox-sensitive catalytic Cys residues of Tyr and maPK phosphatases, the oxidation of which reversibly abolishes enzymatic activity 109 .”
Protein tyrosine phosphatases: from genes, to function, to disease (2006, background): “Attention was drawn to the PTPs as targets of ROS because the signature motif of this family, (I/V)HCXXGXXR(S/T), contains an invariant cysteine residue which, due to the unique environment of the PTP active site, is characterized by an extremely low pKα”
Oxidative Stress, Prooxidants, and Antioxidants: The Interplay (2014, background): “Specific examples of phosphatases known to be regulated in this manner are PTP1b, PTEN, and MAPK phosphatases [89].”