Faculty Opinions recommendation of IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity.

By R. Vile. 2001

946 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b8a71263e6b62b2a0f880130f526df09cfe13a42

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In Oncology

Citations in the corpus

Cytokines in Cancer Immunotherapy (2011, background): “increased risk of spontaneous and chemically-induced tumors compared to controls [1,3,26,61].”
The Immunological Synapse (2014, neutral): “from cancer (1, 2), but also participate in destructive autoimmunity (3, 4).”
The therapeutic promise of the cancer stem cell concept. (2010, background): “Similarly, in experimental model systems, immunocompromised animals such as SCID and Rag–/– mice, which each lack T and B cells, exhibit substantially increased rates of spontaneous malignancies (74).”
New insights into cancer immunoediting and its three component phases — elimination, equilibrium and escape (2014, neutral): “Whereas one body of work has clearly established the capacity of chronic inflammation to initiate and promote cancer [1], a second set of studies from other laboratories, including our own, has revealed that an intact immune system can prevent/ control and shape/promote cancer by a process we call ‘”
The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints (2014, neutral): “These findings are in concordance with multiple studies in murine models demonstrating that Th1 / cytotoxic T lymphocyte (CTL) dominant immune responses are antitumorigenic (4) while Th17 dominant responses are typically pro-carcinogenic (5).”
Checkpoint Blockade Cancer Immunotherapy Targets Tumour-Specific Mutant Antigens (2014, methodology): “epitope predictions, we modified our method as follows: (1) mutation calls from cDNA Capture Sequencing14 were translated to corresponding protein sequences, pipelined through three MHC class I epitope-binding algorithms and a median binding affinity calculated for each predicted epitope; (2) epitop”
NK cells and cancer immunosurveillance (2008, background): “Interestingly, mice deficient for both RAG2 and STAT1 have been reported to spontaneously develop adenocarcinoma at higher rates as compared with mice deficient only for RAG2, implicating NK cells in tumour immunosurveillance (Shankaran et al., 2001; Dunn et al., 2004; Swann and Smyth, 2007).”
Mitochondrial DNA in inflammation and immunity (2020, neutral): “Efficient T-cell responses to tumour cells is a critical step to durable cancer treatment control [118].”
Cancer risk following organ transplantation: a nationwide cohort study in Sweden (2003, background): “Moreover, recent experimental data from immunodeficient double-knockout mice show increased incidence of several spontaneous tumour types (Shankaran et al, 2001).”
CD4⁺ follicular helper T cell infiltration predicts breast cancer survival. (2013, neutral): “Tumor-associated Th1 cytokines, lead by IFN-γ , have consistently been linked with more potent antitumor immune responses in a variety of solid tumors (59, 60), with recent research showing that tumor-specific Th1 cells can effectively control tumor development (61, 62).”
Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function (2006, background): “20061104 2691 Evidence that host immunity plays a critical role in limiting tumor outgrowth in the early stages of tumorigenesis supports the notion of immune surveillance (1, 2).”