The Immunological Synapse
By Michael Loran Dustin. Cancer immunology research, 2014
695 citations recorded by the source corpus.
The molecular interactions underlying regulation of the immune response take place in a nanoscale gap between T cells and antigen-presenting cells, termed the immunological synapse. If these interactions are regulated appropriately, the host is defended against a wide range of pathogens and deranged host cells. If these interactions are disregulated, the host is susceptible to pathogens or tumor escape at one extreme and autoimmunity at the other. Strategies targeting the synapse have helped to establish immunotherapy as a mainstream element in cancer treatment. This Masters' primer will cover the basics of the immunological synapse and some of the applications to tumor immunology. Cancer Immunol Res; 2(11); 1023–33. ©2014 AACR.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/332491f6114e307be862407ce62c16e5e7c5ae5e
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Citations in the corpus
- HIV: cell binding and entry. (2012, background): “…the mechanism of virological synapse formation remains unclear. a4b7 integrin has been reported to bind gp120; induce activation of LFA-1 (aLb2 integrin), which contributes to formation of the immunologic synapse (reviewed in Bromley et al. 2001); and subsequently augment infection Figure 3.”
- Cytokines in Radiobiological Responses: A Review (2012, positive): “For example, when specific T cells recognize antigen presented by dendritic cells, the latter can produce IL-1 and TNF-a that aid in formation of the immunological synapse that activates T cells (4) to acquire IL-2R, and so that IL-2 can drive their proliferation, differentiation and activation to p”
- Cytotoxic CD8+ T cells in cancer and cancer immunotherapy (2020, background): “By homing towards chemokine and integrin gradients on APCs or target cells, activated CD8 T cells form immunological synapses between their supramolecular activation complex and adhesion molecules (such as intercellular adhesion molecule) on the target-cell surface.(8) To confirm the nature of the t”