CD4⁺ follicular helper T cell infiltration predicts breast cancer survival.

By C. Gu-Trantien, S. Loi, S. Garaud, C. Equeter, M. Libin, A. de Wind, M. Ravoet, H. Le Buanec, C. Sibille, G. Manfouo-Foutsop and 14 more. Journal of Clinical Investigation, 2013

939 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/5541baa0d3abb2b5f7b1533833cb97c5f7fba514

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Citations in the corpus

The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014. (2015, methodology): “The presence of follicular helper (Tfh) cells, the newest CD4+ subset, was recently positively associated with patient outcome both in the adjuvant and neoadjuvant settings [16].”
Presence of B cells in tertiary lymphoid structures is associated with a protective immunity in patients with lung cancer. (2014, result): “In that, our strategy parallels the recent work published by GuTrantien and coworkers (43), who showed that tumor infiltration by CXCL13producing CD4(1) follicular helper T cells, one of the major partners of follicular B cells in TLS, is associated with organized immune structures and long-term pos”
Tertiary lymphoid structures in cancer (2022, background): “In addition, multiple gene expression signatures associatedwith TLSs have shown positive prognostic value, including a plasma cell signature in ovarian cancer (29), a TFH signature in head and neck squamous cell carcinoma (114), and various gene signatures associated with lymphoid chemokines (includ”
The Consensus Molecular Subtypes of Colorectal Cancer (2015, methodology): “is supported by grants from the Dutch Cancer Society (UVA2011-4969, UVA2014-7245), Worldwide Cancer Research (14-1164), the Maag Lever Darm Stichting (MLDS-CDG 14-03) and the European Research Council (ERG-StG 638193).”
T follicular helper cell biology: A decade of discovery and diseases (2019, background): “Tfh-related cells have been positively associated with long term survival of humans with breast cancer or colorectal cancer (Bindea et al., 2013; Gu-Trantien et al., 2013).”
Follicular Helper T Cells. (2016, neutral): “By contrast with their lymphoid tumor-promoting effects, Tfh cells may have protective roles in nonlymphoid tumors: They can be abundant within inflammatory infiltrates in breast cancer, and their presence and ability to organize tertiary lymphoid structures within tumors has been linked with improv”