The Nucleolus under Stress
By Séverine Boulon, B. Westman, Saskia Hutten, François-Michel Boisvert, Angus I. Lamond. Molecules and Cells, 2010
1,052 citations recorded by the source corpus.
Cells typically respond quickly to stress, altering their metabolism to compensate. In mammalian cells, stress signaling usually leads to either cell-cycle arrest or apoptosis, depending on the severity of the insult and the ability of the cell to recover. Stress also often leads to reorganization of nuclear architecture, reflecting the simultaneous inhibition of major nuclear pathways (e.g., replication and transcription) and activation of specific stress responses (e.g., DNA repair). In this review, we focus on how two nuclear organelles, the nucleolus and the Cajal body, respond to stress. The nucleolus senses stress and is a central hub for coordinating the stress response. We review nucleolar function in the stress-induced regulation of p53 and the specific changes in nucleolar morphology and composition that occur upon stress. Crosstalk between nucleoli and CBs is also discussed in the context of stress responses.
Subfields: Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/5644fa23a7057d17c3ed3bef550ab4898ce6fff0
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Citations in the corpus
- A census of human RNA-binding proteins (2014, neutral): “nonfunctional or transcriptionally inactive repeats (Boulon et al., 2010).”
- The heat shock response: life on the verge of death. (2010, background): “Nucleoli, the sites of ribosome assembly, swell, and large granular depositions composed of incorrectly processed ribosomal RNAs and aggregating ribosomal proteins become visible (Welch and Suhan, 1985; see related review in this issue by Boulon et al., 2010).”
- DEAD-Box Helicases: Sensors, Regulators, and Effectors for Antiviral Defense (2020, background): “Nucleoli form as sites of concentrated processing factors around clusters of rDNA genes, and liquid–liquid phase separation drives the organization of subcompartments in which rRNA is cleaved and modified [49,50].”
- Biogenesis and Function of Nuclear Bodies (2011, background): “In summary, the concept of the nucleolus being “plurifunctional” was first raised in 1998 [38] and is now widely accepted [27, 29].”