How Common are Extra-ribosomal Functions of Ribosomal Proteins?

By J. R. Warner, K. B. Mcintosh. Molecules and Cells, 2009

722 citations recorded by the source corpus.

Ribosomal proteins are ubiquitous, abundant, and RNA-binding, prime candidates for recruitment to extra-ribosomal functions. Indeed, they participate in balancing the synthesis of the RNA and protein components of the ribosome itself. An exciting new story is that ribosomal proteins are sentinels for the self-evaluation of cellular health. Perturbation of ribosome synthesis frees ribosomal proteins to interface with the p53 system, leading to cell cycle arrest or to apoptosis. Yet in only a few cases can we clearly identify the recruitment of ribosomal proteins for other extra-ribosomal functions. Is this due to a lack of imaginative evolution by cells and viruses, or to a lack of imaginative experiments by molecular biologists?

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1623c59dba91176eab6786e69a6301f4255aa7d7

How researchers see this paper

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In Molecular Biology

1. Benjamin L. Ebert
2. Thomas Tuschl
3. Hua Lu
4. M. Hafner
5. S. Gerstberger
6. M. Barna
7. A. Narla
8. Xiaoping Zhou

Citations in the corpus

• Ribosomal proteins: functions beyond the ribosome. (2015, background): “For further reading, we would like to refer readers to other reviews on the related subjects (Warner and McIntosh, 2009; Zhang and Lu, 2009; Boulon et al., 2010; Zhou et al., 2012; de Las Heras-Rubio et al., 2014).”
• In brief (2011, neutral): “Interestingly, the literature also indicates that ribosomal defects induce apoptotic cell death, although the underlying mechanism is not understood (Warner and McIntosh, 2009).”
• A census of human RNA-binding proteins (2014, background): “48 expressed RBPs may reflect extra-ribosomal roles (Warner and McIntosh, 2009) or tissue-specific adaptations in composition of ribosomes that regulate translation of subsets of proteins (Xue and”
• Ribosome mediated specificity in Hox mRNA translation and vertebrate tissue patterning (2011, positive): “For some RPs, dramatic differences in expression levelsmay reflect extraribosomal functions (Warner and McIntosh, 2009).”
• Ribosomopathies: human disorders of ribosome dysfunction. (2010, background): “[2] Several ribosomal proteins have extraribosomal functions including replication and DNA repair, so mutations in ribosomal proteins may have effects that are independent of the protein translation machinery.[7, 8]”