Exosomes: from biogenesis and secretion to biological function.

By Sascha Keller, M. Sanderson, Alexander Stoeck, P. Altevogt. Immunology Letters, 2006

899 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b7e47cbcdc1c75f95ba45d41c9c981354539e68c

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Citations in the corpus

Cellular Internalization of Exosomes Occurs Through Phagocytosis (2010, background): “The presence of exosomes in urine (10,11), circulating blood (12), ascites (13) and cerebrospinal fluid (14) in vivo suggests a role in intercellular communication (15,16).”
Interaction and uptake of exosomes by ovarian cancer cells (2011, background): “Exosomes are small membrane vesicles between 40-100 nm in diameter that are secreted by various cell types, including tumor cells, neurons, B- and T- lymphocytes, intestinal epithelial cells [1-3] and in physiological fluids [3,4].”
Exosomal cell-to-cell transmission of alpha synuclein oligomers (2012, background): “Exosomes can interact with recipient cells in different ways, including endocytosis, fusion with the plasma membrane, receptorligand-binding or attachment [78,95-97].”
Naturally Occurring Exosome Vesicles as Potential Delivery Vehicle for Bioactive Compounds (2019, background): “The attention given to animal-derived exosomes as delivery vehicles for bioactive compounds is because of their biocompatibility, biorecognition, target specificity, and stability (Keller et al., 2006).”
miR-21: a small multi-faceted RNA (2008, background): “Exosomes are the ‘bioactive vesicles’ released by many tumours (as well as some normal cells of various origins) that are taken up by surrounding host cells, and therefore function to promote intercellular communication [105].”
Classification, Functions, and Clinical Relevance of Extracellular Vesicles (2012, background): “…vesicles that are present in many and perhaps all biological fluids, including urine, blood, ascites, and cerebrospinal fluid (Pisitkun et al., 2004; Caby et al., 2005; Keller et al., 2006; Vella et al., 2008), fractions of body fluids such as serum and plasma, and cultured medium of cell cultures.”
Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation (2012, positive): “A growing body of research has implicated extracellular vesicles (EVs), membraneous sacs released by a variety of cells, in diverse physiological and patho-physiological conditions [1–9].”
Exosomes and their roles in immune regulation and cancer. (2015, background): “[16] Keller S, Sanderson MP, Stoeck A, Altevogt P.”
Membrane Vesicle Release in Bacteria, Eukaryotes, and Archaea: a Conserved yet Underappreciated Aspect of Microbial Life (2012, background): “travels to the cell surface, fuses, and releases exosomes into the surrounding 232 environment (Figure 3B, (37, 55)).”
Exosomes in Cancer Development, Metastasis and Drug Resistance: A Comprehensive Review (2013, positive): “1) is a very tightly regulated process governed by multiple signaling molecules and begins with the receptor activation that is unique for each type of cell [31].”
Body fluid derived exosomes as a novel template for clinical diagnostics (2011, background): “Depending on the cellular origin, exosomes contain various cellular proteins that may be different from proteins that are normally located in the plasma membrane including MHC molecules, tetraspanins, adhesion molecules and metalloproteinases [1,2,7].”
Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer (2008, neutral): “18 7 11 1 0 0 37c Aex + GM-CSF E1 +(1-2) 0 0 0 0 0 1”
Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. (2010, background): “Exosomes are formed from multivesicular bodies with a bilipid membrane (Fevrier and Raposo, 2004; Keller et al., 2006).”