Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

By Hina Kalra, Richard J. Simpson, H. Ji, E. Aikawa, P. Altevogt, P. Askenase, V. Bond, F. Borràs, X. Breakefield, V. Budnik and 46 more. PLoS Biology, 2012

1,306 citations recorded by the source corpus.

Vesiclepedia is a community-annotated compendium of molecular data on extracellular vesicles.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/749b84f1c05f5e9ef49cad5ff162dde423ec9325

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. C. Théry
2. T. Whiteside
3. G. Raposo
4. Marina Colombo
5. Suresh Mathivanan
6. Hina Kalra
7. A. Llorente
8. Richard J. Simpson

In Immunology

1. C. Théry
2. G. Raposo
3. Richard J. Simpson
4. Marina Colombo
5. Suresh Mathivanan
6. W. Stoorvogel
7. V. Pascual
8. Moshe Oren

In Molecular Biology

1. C. Théry
2. G. Raposo
3. Suresh Mathivanan
4. T. Whiteside
5. Marina Colombo
6. Richard J. Simpson
7. Hina Kalra
8. A. Llorente

Citations in the corpus

• Biogenesis and secretion of exosomes. (2014, neutral): “Members of the ESCRT-II and ESCRT-III complexes are consistently found in proteomic analyses of various exosomes (see Vesiclepedia and EVpedia).”
• Biological properties of extracellular vesicles and their physiological functions (2015, background): “Lipids have been included in the EV databases such as Vesiclepedia (34) and EVpedia (35), and specific reviews on EV lipids are also available (104,230 232).”
• Focus on Extracellular Vesicles: Introducing the Next Small Big Thing (2016, background): “org), a community annotation compendium for all EVs [130], have allowed researchers to successively deposit identified constituents of exosomes and provide a general overview of their molecular composition [127].”
• Lipids in exosomes: Current knowledge and the way forward. (2017, background): “Exosomes have a complex composition including proteins, nucleic acids, lipids and other metabolites [5,6].”
• Plasma Proteome Database as a resource for proteomics research: 2014 update (2013, background): “There are 318 EV proteins annotated in PPD and each is linked to Exocarta and Vesiclepedia, both manually curated resources for proteins, messenger RNA, micro RNA and lipids reported from EVs including exosomes (42,43).”
• Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers (2020, background): “Despite the public availability of several EVP protein databases, (e.g., Vesiclepedia, EVpedia, ExoCarta) (Kalra et al., 2012; Kim et al., 2015; Mathivanan and Simpson, 2009), much remains unknown about EVP proteomes, including: (1) markers for reliable isolation of EVPs in humans, regardless of tis”
• Mechanisms of mesenchymal stem/stromal cell function (2016, neutral): “same source by different methods may differ in amount and/or content [179–181].”
• Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes (2016, background): “, 100K pellets) secreted by mouse DCs (20) and other cells (21, 22), and listed by us as components of “canonical exosomes” (23), but our results now show that only a restricted subset of these proteins represent sEV-specific markers, among which a subfraction is associated to tetraspaninenriched EV”
• Tumor-derived exosomes and their role in cancer progression (2016, background): “A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript this type of correlative data, interest in molecular profiling of the entire proteome of tumorderived exosomes by mass spectrometry has led to the accumulation of a large volume of proteomics data now available in the da”
• EVpedia: an integrated database of high-throughput data for systemic analyses of extracellular vesicles (2013, background): “For example, many mass spectrometry-based proteomic studies, microarray or next-generation sequencing-based transcriptomic studies, (16,17), which was recently updated into Vesiclepedia (http://www.microvesicles.org; 18).”
• Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes (2013, background): “EVs can be broadly classified into three main classes, based primarily on their size and presumed biogenetic pathways: (a) apoptotic bodies (ABs), 800 5,000 nm diameter and released by cells undergoing programmed cell death, (b) microvesicles (MVs), also referred to as shedding MVs, are large membra”