Cellular Internalization of Exosomes Occurs Through Phagocytosis

By Du Feng, Wen-long Zhao, Y. Ye, X. Bai, Rui-Qin Liu, Lei-fu Chang, Qiang Zhou, Sen‐fang Sui. Traffic : the International Journal of Intracellular Transport, 2010

961 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3d86accbd7d9bc1711d55febcea834b09d6a7b89

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Citations in the corpus

Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1 (2013, background): “1H), which argues against that exosome transfer is restricted to specific cell-types as has previously been suggested (17).”
Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine (2017, background): “Exosomes may subsequently be internalized by other cells principally by phagocytosis, fusion with the cell membrane and receptor–ligand interaction, allowing the release of their contents into the cytoplasm [168,169].”
Exosomes in cancer: small particle, big player (2015, background): “Phagocytic cells have a greater uptake of exosomes than non-phagocytic cells [16].”
Tetraspanins in Extracellular Vesicle Formation and Function (2014, background): “Regarding EV uptake, phagocytic processes dependent on dynamin2 and PI3K seem to be the dominant mode of EV uptake into recipient cells (115).”
Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes (2019, background): “Exosomes derived from erythroleukemia cells were internalized through phagocytosis or macropinocytosis [223].”
Exosome Uptake through Clathrin-mediated Endocytosis and Macropinocytosis and Mediating miR-21 Delivery* (2014, background): “It has been reported that exosomes derived from erythroleukemia cells or oligodendroglia cells were internalized through phagocytosis or macropinocytosis, respectively (20, 21).”
Routes and mechanisms of extracellular vesicle uptake (2014, background): “In phagocytic cells, inhibition of dynamin2 (85,86) prevented almost all EV internalization activity (24,27,28).”
Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy. (2012, background): “Some have hypothesized that exosomes and microvesicles can be phagocytosed by recipient cells (112,113) or fuse directly with the plasma membrane (114).”