miR-21: a small multi-faceted RNA

By Anna M. Krichevsky, Galina Gabriely. Journal of Cellular and Molecular Medicine, 2008

992 citations recorded by the source corpus.

•  miR‐21 expression in cancer and other diseases •  Mechanisms of miR‐21 elevation in cancer: multi‐level regulatory control •  Transcriptional control •  Post‐trancriptional regulation •  miR‐21 functions in cancer •  Identification of direct miR‐21 targets •  miR‐21 in gliomas: targeting cell cycle, apoptosis and invasion •  miR‐21 networking and feedback regulation •  miR‐21 as a diagnostic and prognostic marker •  Potential therapeutic target •  Acknowledgements

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/fa096773b1625764492f45a7ba621ec6dba46727

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In Cancer Research

1. Sakari Kauppinen
2. Gregory J. Hannon

In Molecular Biology

1. Sakari Kauppinen
2. Gregory J. Hannon
3. C. Ruse
4. V. Narry Kim
5. Phillip D. Zamore
6. Scott M. Hammond
7. David P. Bartel
8. T. Rana

Citations in the corpus

• Silencing of microRNA families by seed-targeting tiny LNAs (2011, background): “Inhibition of miR-21 function by an 8-mer tiny LNA To test our knockdown strategy in cultured cells, we first chose to target miR-21, a potentially oncogenic miRNA that is upregulated and abundant in many solid tumors and in most cancer cell line”