Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells.

By E. Smirnova, L. Griparić, D. Shurland, A. Bliek. Molecular Biology of the Cell, 2001

1,936 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b7ce5b33f124888c12e0602119671093a42024c6

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In Molecular Biology

1. D. C. Chan
2. R. Youle
3. Hsiuchen Chen
4. M. Liesa
5. L. Scorrano
6. D. Seol
7. Seon-Yong Jeong
8. A. M. van der Bliek

Citations in the corpus

• Mitochondrial fusion and fission in mammals. (2006, background): “Because Drp1 is a dynamin family GTPase, it is thought to act as a mechanochemical enzyme that uses GTP hydrolysis to drive constriction at mitochondrial fission sites (Shaw & Nunnari 2002, Smirnova et al. 2001).”
• Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. (2004, background): “Inhibition of Drp1 GTPase activity with a dominant negative protein (Drp1 K38A ) prevents the mitochondrial fragmentation seen during apoptosis and delays the process of cell death (Frank et al., 2001; Karbowski et al., 2002), suggesting that mitochondrial fission is a required step in apoptosis.”
• Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells (2010, background): “The Mff gene encodes at least nine different splice variants, although their functional difference is not known (Gandre-Babbe The fundamental molecular mechanisms of mitochondrial fission seem to be conserved across species because the mammalian homologues of yeast Fis1 (hFis1 for human homologues) ”
• The role of mitochondria in apoptosis. (2008, background): “Mitochondrial fission machinery consists of the proteins Fis1 (10) and dynamin related protein 1 (Drp1) (11).”
• Mitochondrial dynamics in mammalian health and disease. (2009, background): “The mitochondrial phenotype induced by DRP1 K38A is the same as that observed in cells where DRP1 expression is reduced by siRNA (97, 240, 273, 274).”