Resetting central and peripheral circadian oscillators in transgenic rats.

By S. Yamazaki, R. Numano, Michikazu Abe, A. Hida, R. Takahashi, M. Ueda, G. Block, Y. Sakaki, M. Menaker, H. Tei. Science, 2000

1,913 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Physiology, Plant Science

View Paper: https://www.semanticscholar.org/paper/b6ec96fd34b9f839764320b65799e1be81f6ffdb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. J. Takahashi
2. C. H. Ko
3. U. Schibler
4. C. Green
5. John B. Hogenesch
6. Steve A. Kay
7. Ethan D. Buhr
8. Kazuyuki Aihara

In Physiology

1. J. Takahashi
2. U. Schibler
3. Kazuyuki Aihara
4. Luonan Chen
5. C. Green
6. C. H. Ko
7. Ethan D. Buhr
8. John B. Hogenesch

In Plant Science

1. J. Takahashi
2. C. H. Ko
3. John B. Hogenesch
4. Ethan D. Buhr
5. D. Weaver
6. C. Green
7. U. Schibler
8. Steve A. Kay

Citations in the corpus

• Extensive and divergent circadian gene expression in liver and heart (2002, methodology): “For each gene we required: (1) a positive correlation between the first and second days (selects for a daily repetition); (2) a negative autocorrelation at 12 h (removes ultradian oscillations and noise); (3) an amplitude threshold (removes trivial oscillations); and (4) a threshold for the maximum ”
• Physiological significance of a peripheral tissue circadian clock (2008, background): “Under conditions of continuous food availability, the SCN clock sets the phases of peripheral tissue clocks (6).”
• The Bird Clock: A Complex, Multi-Oscillatory and Highly Diversified System (2004, background): “…circadian oscillators function hierarchically: the SCN of the anterior hypothalamus contain self-sustained circadian oscillators that act as a central pacemaker and entrain oscillators present in the peripheral tissues, for example, the liver, lungs and skeletal muscle (Yamazaki et al., 2000).”
• Mop3 is an essential component of the master circadian pacemaker in mammals. (2000, background): “As examples, the mouse and Silver et al., 1996; Yamazaki et al., 2000). human genomes encode three homologs of per (Per1, Circadian oscillators in Drosophila, Neurospora, and Per2, and Per3) and two homologs of cry (Cry1 and Cry2) (reviewed in King and Takahashi, 2000).”
• The “Other” Circadian System: Food as a Zeitgeber (2002, background): “Using transgenic rats with the PER1 promoter linked to a luciferase reporter (Per1-luc), Yamazaki et al. (2000) reported rhythmic gene expression in explants of the SCN, liver, skeletal muscle, and lung.”
• Differential Control of Bmal1 Circadian Transcription by REV-ERB and ROR Nuclear Receptors (2005, background): “…a major role in orchestrating rhythmicity throughout the organism, most tissues and even isolated cells possess their own and ostensibly similar circadian clocks (Balsalobre et al., 1998; Yamazaki et al., 2000; Nagoshi et al., 2004; Welsh et al., 2004; Yoo et al., 2004; Carr and Whitmore, 2005).”
• CENTRAL AND PERIPHERAL CIRCADIAN CLOCKS IN MAMMALS (2012, background): “These mediators include members of the nuclear receptor family of transcription factors , many of which exhibit circadian rhythms of transcription within the liver and other metabolically relevant tissues (Yang et al. 2006).”
• A circadian clock in macrophages controls inflammatory immune responses (2009, methodology): “of PER2::LUC mice (20) and a Per1:luc rat (4) were cultured individually on”
• Molecular components of the Mammalian circadian clock. (2013, background): “Most tissues and cell types have been found to display circadian patterns of gene expression when isolated from the SCN (Balsalobre et al. 1998; Tosini and Menaker 1996; Yamazaki et al. 2000; Abe et al. 2002; Brown and Azzi 2013).”