Extensive and divergent circadian gene expression in liver and heart

By Kai-Florian Storch, O. Lipan, I. Leykin, N. Viswanathan, F. Davis, Wing H. Wong, C. Weitz. Nature, 2002

1,577 citations recorded by the source corpus.

Subfields: Aging, Endocrine and Autonomic Systems, Plant Science

View Paper: https://www.semanticscholar.org/paper/7f6d0dc8d9351185d8cdcebb070b0d9f51683a3d

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Citations in the corpus

Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences and Countermeasures (2016, positive): “Although some genes may be rhythmic in multiple tissues, their phases often differ between and even within tissues, and rhythmic gene expression is largely organ-specific (68, 69).”
The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. (2006, background): “, c-Myc, cyclin D1, and Wee1) are key cell cycle regulators (Panda et al., 2002; Storch et al., 2002).”
Rhythmic histone acetylation underlies transcription in the mammalian circadian clock (2003, background): “These slave oscillators, in turn, generate local rhythms in physiological processes that control tissue-specific function”
Molecular components of the Mammalian circadian clock. (2013, background): “In the liver, between 330 and 450 genes are expressed with a circadian rhythm (Panda et al. 2002a; Storch et al. 2002).”
Molecular components of the mammalian circadian clock. (2006, background): “This is also seen in other comparisons of different tissues ( 61 ).”
Studying and modelling dynamic biological processes using time-series gene expression data (2012, background): “…signals (such as stress 2 or pathogens 8,9 ); developmental processes that have a clear starting point (for example, embryonic development 10–13 ); and cyclic internal processes in which the entire cell population can be synchronized (for example, the cell cycle 14–18 and circadian clock 19–21 ).”
Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock. (2006, background): “Since different tissues have characteristic sets of genes with clock-regulated timing and amplitude of expression (Panda et al. 2002a; Storch et al. 2002), it is likely that the circadian clock is involved in control of homeostasis in different organs.”
Harmonics of Circadian Gene Transcription in Mammals (2009, background): “Consequently, studies have been performed in several model systems to identify rhythmically expressed genes in both central and peripheral tissues [8,11–21].”
A clockwork web: circadian timing in brain and periphery, in health and disease (2003, background): “DNA microarrays indicate that beyond the core loop, about 5–9% of the transcriptome is under circadian control in the liver, with a similar proportion in the heart and in the SC”
Genomic approaches to understanding population divergence and speciation in birds (2015, background): “In this case, the geographic distribution of allele frequencies across a hybrid zone is related to several parameters, including the age of the zone of contact and the extent of reproductive isolation in the zone (Szymura and Barton 1986).”
Information criterion-based clustering with order-restricted candidate profiles in short time-course microarray experiments (2009, positive): “Examples of such studies include response to temperature changes and other stress conditions [4], immune response [5], developmental studies [6], and various systems in the cell [7].”
A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. (2004, background): “…been shown to cycle in the SCN, liver, heart (Akhtar et al., 2002; Panda et al., 2002a; Preitnermutation did not affect activation by C/ebp , which likely activates through different elements, such as the many et al., 2002; Storch et al., 2002; Ueda et al., 2002), kidney, and aorta (see above).”
Permutation test for periodicity in short time series data (2006, positive): “In data sets of 12 time points [5] and [3]) all three algorithms revealed that 20–25% of all genes followed a circadian rhythm with confidence levels of at least 95%.”
Physiological significance of a peripheral tissue circadian clock (2008, background): “A number of genes expressed in the liver that function in hepatic glucose metabolism exhibit robust circadian regulation (18–20), and mice with altered circadian clocks in all tissues have evidence of impaired gluconeogenesis (19), raising the possibility that the liver circadian clock plays a signi”
Circadian rhythms from multiple oscillators: lessons from diverse organisms (2005, background): “In mammals, up to 10% of the transcriptome shows a circadian rhythm in mRNA accumulation in any given tissue, whereas less than 1% shows a circadian expression pattern across multiple tissue”