Mop3 is an essential component of the master circadian pacemaker in mammals.

By M. Bunger, Lisa D. Wilsbacher, S. Moran, C. Clendenin, Laurel A. Radcliffe, John B. Hogenesch, M. Simon, J. Takahashi, Christopher A. Bradfield. Cell, 2000

1,601 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Physiology, Plant Science

View Paper: https://www.semanticscholar.org/paper/bcf12c46a7468cd0e94035b37450634fc01250ad

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. J. Takahashi
2. U. Albrecht
3. C. H. Ko
4. Satchidananda Panda
5. U. Schibler
6. John B. Hogenesch
7. E. Maywood
8. Cheng Chi Lee

In Physiology

1. J. Takahashi
2. U. Albrecht
3. U. Schibler
4. Satchidananda Panda
5. C. H. Ko
6. John B. Hogenesch
7. G. FitzGerald
8. Paolo Sassone-Corsi

In Plant Science

1. J. Takahashi
2. C. H. Ko
3. U. Albrecht
4. John B. Hogenesch
5. Satchidananda Panda
6. D. Weaver
7. U. Schibler
8. Cheng Chi Lee

Citations in the corpus

• Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. (2001, background): “This resultclock (Bunger et al., 2000).”
• Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. (2001, background): “…mCry12/2, mCry22/2 double-knock- tween mice bearing mutations of mPer1 and mPer2, each of the three mPer genes has a distinct function inout mice (Bunger et al., 2000; van der Horst et al.,1999; Vitaterna et al., 1999), and in the mPer1/mPer2 double- the SCN circadian clockwork. mutant mice…”
• Mammalian circadian biology: elucidating genome-wide levels of temporal organization. (2004, background): “In mammals, two core clock genes, Clock and Bmal1 (Mop3), encode proteins that are members of the basic helix-loop-helix (bHLH)-PAS (Period-Arnt-Single-minded) transcription factor family (31, 64, 86, 103).”
• microRNA modulation of circadian-clock period and entrainment. (2007, neutral): “In the positive limb, heterodimers of the transcription factors, CLOCK and BMAL1, induce transcription of the period (Per1, Per2, Per3) and cryptochrome (Cry1, Cry2) genes at the Ebox elements within their promoters (Gekakis et al., 1998; Bunger et al., 2000).”
• BMAL1 and CLOCK, Two Essential Components of the Circadian Clock, Are Involved in Glucose Homeostasis (2004, background): “This response was more pronounced in the former, consistent with the comparative severity of the molecular and behavioral phenotypes between the Bmal1 / and Clock animals (King et al. 1997; Bunger et al. 2000).”
• Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock. (2006, methodology): “Mice were genotyped by PCR as previously described (Bunger et al. 2000).”
• Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus (2002, background): “Mice with disrupted Bmal1 , or that are deficient in both Per1 and Per2 , exhibit the most severe phenotype: they are arrhythmic immediately after placement in constant darknes”
• System-level identification of transcriptional circuits underlying mammalian circadian clocks (2005, background): “Genetic analyses have identified numerous mammalian clock genes, including two basic helix-loop-helix–PAS transcription factor”
• Molecular components of the mammalian circadian clock. (2006, background): “Furthermore, mice homozygous for a null allele of Bmal1 have severely disrupted behavioral and molecular rhythms ( 13 ).”