Differential Control of Bmal1 Circadian Transcription by REV-ERB and ROR Nuclear Receptors

By F. Guillaumond, H. Dardente, V. Giguère, N. Cermakian. Journal of Biological Rhythms, 2005

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Molecular components of the mammalian circadian clock. (2006, background): “The REVERB and ROR proteins then compete for retinoic acid-related orphan receptor response element (RORE) binding sites within the promoter of Bmal1 where ROR proteins initiate Bmal1 transcription and REV-ERB proteins inhibit it (Preitner et al. 2002; Guillaumond et al. 2005).”
Molecular components of the Mammalian circadian clock. (2013, background): “The REVERB and ROR proteins then compete for retinoic acid-related orphan receptor response element (RORE) binding sites within the promoter of Bmal1 where ROR proteins initiate Bmal1 transcription and REV-ERB proteins inhibit it (Preitner et al. 2002; Guillaumond et al. 2005).”
Circadian genes, rhythms and the biology of mood disorders. (2007, background): “In addition, there is an adjoining loop in which CLOCK/BMAL1 activates the transcription of Rev-erbα and Rorα (Sato et al., 2004;Guillaumond et al., 2005).”
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “…in the control of brain and muscle ARNT-like 1 (BMAL1 or ARNTL) expression and may be part of several other regulatory feedback loops [Akashi and Takumi, 2005; Albrecht, 2002; Gachon et al., 2004; Guillaumond et al., 2005; Nakajima et al., 2004; Preitner et al., 2002; Triqueneaux et al., 2004].”