How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

By J. Chipuk, Douglas R. Green. Trends in Cell Biology, 2008

1,023 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b668f183aae79bc360c13a3058ba52ec23b44211

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. V. Weis
2. Douglas R. Green
3. Junying Yuan
4. E. K. Kim
5. E. Choi
6. J. Li
7. K. Yip
8. John Calvin Reed

In Molecular Biology

1. Douglas R. Green
2. John Calvin Reed
3. F. Llambi
4. K. Yip
5. J. Chipuk
6. V. Weis
7. Junying Yuan
8. David W. Andrews

Citations in the corpus

• Pathological roles of MAPK signaling pathways in human diseases. (2010, background): “p38 phosphorylates the tumor suppressor p53, which then induces the expression of the pro-apoptotic protein Bax, which in turn induces the permeabilization of the mitochondrial outer membrane [81], in dopaminergic neurons of the ventral midbrain in mice [82] (Fig.”
• Cellular mechanisms of Cnidarian bleaching: stress causes the collapse of symbiosis (2008, background): “One intrinsic pathway of apoptosis initiation involves the release of pro-apoptotic molecules from the mitochondria, including apoptosis inducing factor (AIF) and cytochrome c, which goes on to activate caspases (Chipuk and Green, 2008; Lorenzo et al., 1999).”
• Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax. (2008, background): “Despite extensive study, how the Bcl-2 family proteins regulate MOMP remains speculative (Chipuk and Green, 2008).”
• Homeostasis of naive and memory T cells. (2008, background): “In addition, Bcl-2 and Mcl-1 appear to block the family of BH-3-only Bcl-2-related molecules, including Bim and Bid, which directly activate Bax and Bak; Bcl-2 and Mcl-1 also interact with several other members of this family, including Bad and PUMA, which activate Bax and Bak indirectly by function”
• Bcl-2 family proteins and cancer (2008, background): “Induction of MOMP correlates with oligomerization of Bax and/or Bak in the outer mitochondrial membrane, which is opposed by antiapoptotic proteins such as Bcl-2 and Bcl-XL (Eskes et al., 2000; Wei et al., 2000; Chipuk and Green, 2008).”
• Anti-apoptosis and cell survival: a review. (2011, background): “This family contains both negative and positive regulators of apoptosis with Bax being the most studied pro-apoptotic member while Bcl-2 the most studied anti-apoptotic member [10,74].”
• The BCL-2 Family Reunion (2010, background): “BH3-only proteins in this process is undisputed (Chipuk and Green, 2008).”
• Caspases in apoptosis and beyond (2008, background): “The BH3-only protein activation above certain crucial threshold overcomes the inhibitory effect of the anti-apoptotic Bcl-2 family and promotes the assembly of Bak–Bax oligomers within the mitochondrial outer membranes, which leads to the release of cytochrome c (Chipuk and Green, 2008).”