MicroRNA-Directed Cleavage of HOXB8 mRNA

By Soraya Yekta, I. Shih, David P. Bartel. Science, 2004

1,905 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b565a6269a10145ae44433c5b922de700b02e850

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Citations in the corpus

In vivo delivery of miRNAs for cancer therapy: Challenges and strategies (2014, background): “The gene suppression mechanism depends on the degree of complementarity sites between the miRNAs and mRNAs [21,22].”
MicroRNA-Directed Regulation of Arabidopsis AUXIN RESPONSE FACTOR17 Is Essential for Proper Development and Modulates Expression of Early Auxin Response Genesw⃞ (2005, background): “…translation, although plant miRNAs appear to act primarily via mRNA cleavage (Lee et al., 1993; Wightman et al., 1993; Olsen and Ambros, 1999; Hutvágner and Zamore, 2002; Llave et al., 2002; Aukerman and Sakai, 2003; Kasschau et al., 2003; Tang et al., 2003; Chen, 2004; Yekta et al., 2004).”
Metazoan MicroRNAs (2018, background): “In humans and other mammals, however, miRNA-directed slicing has been reported for only 20 cellular transcripts (Yekta et al., 2004; Davis et al., 2005; Shin et al., 2010), one circular RNA (Hansen et al., 2011), and a few viral mRNAs (Sullivan et al., 2005; Barth et al., 2008), and examples of…”
Mapping the Human miRNA Interactome by CLASH Reveals Frequent Noncanonical Binding (2013, positive): “…on mRNAs have been mapped transcriptome wide by crosslinking, immunoprecipitation, and highthroughput sequencing (CLIP-seq), allowing prediction of many miRNA-mRNA interactions (Chi et al., 2009; Hafner et al., 2010a; Zhang and Darnell, 2011) and yielding data consistent with the canonical rules.”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “MicroRNA-directed mRNA cleavage is catalyzed by Ago2, when the target and miRNA are extensively basepaired over regions including the seed and bases 10-11 of the guide [124, 138, 172, 174, 178, 179].”
CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs (2016, background): “They bind thousands of human transcripts through partial complementarity and generally reduce their expression by suppressing mRNA translation and/ or stability.(21-23) In some cases miRNAs may enhance mRNA translation.”
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. (2005, background): “Transcription factors and Hox genes are prime targets for miRNA regulation (Lewis et al. 2003; Yekta et al. 2004).”
Involvement of microRNA in AU-rich element-mediated mRNA instability. (2005, background): “…to the mRNA results in translational repression of the protein-coding genes (Lee et al., 1993; Wightman et al., 1993; Reinhart et al., 2000) or cleavage of mRNA (Yekta et al., 2004) depending on the degree of complementarity (Hutvagner and Zamore, 2002; Doench et al., 2003; Saxena et al., 2003).”
MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma (2007, background): “Lastly, miR-196a and -196b, with a 14-fold overexpression in PDAC compared to normal tissues, were shown to regulate HOXB8 expression involved in limb development (Yekta et al., 2004; Hornstein et al., 2005).”