MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma

By A. Szafranska, T. Davison, Jeremy J. John, T. Cannon, B. Sipos, A. Maghnouj, E. Labourier, S. Hahn. Oncogene, 2007

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miR-155 gene: a typical multifunctional microRNA. (2009, background): “Two independent studies detected a 10-14 fold up regulation of miR-155 in PDAC with respect to normal pancreatic tissue [54, 55].”
Normalization of microRNA expression levels in quantitative RT-PCR assays: identification of suitable reference RNA targets in normal and cancerous human solid tissues. (2008, background): “Moreover, miRNAs show promise in both diagnostic and therapeutic applications (Wu et al. 2006; Szafranska et al. 2007).”
MicroRNAs in development and disease. (2011, background): “miR-196a/b’s role was further emphasized as it was strictly detected in cancer tissue and cell lines but not in normal tissue or in pancreatitis (591).”
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “overexpressed in pancreatic cancer (Lee et al., 2007; Szafranska et al., 2007).”
The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease (2013, positive): “In pancreatic cancer, miR-17, miR-18a, miR-19a and miR19b-1 expression levels are increased.(69,70) Another study also showed that the level of miR-18a in the blood is significantly higher before surgery in patients with pancreatic cancer compared with after surgery, suggesting the possibility that ”