Lysyl oxidase is essential for hypoxia-induced metastasis

By J. Erler, K. Bennewith, Monica Nicolau, N. Dornhöfer, C. Kong, Quynh-Thu Le, Jen-Tsan Ashley Chi, S. Jeffrey, Amato J. Giaccia. Nature, 2006

1,368 citations recorded by the source corpus.

Subfields: Cancer Research, Cardiology and Cardiovascular Medicine, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b5542bde6359f348087ab040b7edd7248d0f51ae

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In Cancer Research

In Cardiology and Cardiovascular Medicine

In Molecular Biology

Citations in the corpus

Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance (2019, background): “Moreover, hypoxia-inducible factor 1 induces production of lysyl oxidase (LOX), which crosslinks type I collagen and other fibrillar collagens, increasing the stiffness of the tumor matrix and enhancing integrin signaling and proliferation (Erler et al., 2006; Levental et al., 2009) (Figure 3).”
EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, positive): “, 2014), which can be modulated by the collagen-crosslinking enzyme lysl oxidase (LOX), may also be important for the creation of pro-metastatic microenvironment (Erler et al., 2009; Erler et al., 2006).”
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. (2007, background): “HIF-1a uniquely activates glycolytic enzyme genes, while HIF-2a preferentially activates VEGF, transforming growth factor-a (TGFa), lysyl oxidase, Oct4, and Cyclin D1 (Baba et al., 2003; Covello et al., 2006; Erler et al., 2006; Gunaratnam et al., 2003; Hu et al., 2003; Wang et al., 2005).”
Tumor microenvironment abnormalities: Causes, consequences, and strategies to normalize (2007, background): “Furthermore, exposure to hypoxia alters tumor cells to be highly invasive and metastatic [Pennacchietti et al., 2003; Erler et al., 2006].”
Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy (2020, background): “of lysyl oxidases generally improves oxygenation (Erler et al., 2006; Rossow et al., 2018).”
Dynamic interplay between the collagen scaffold and tumor evolution (2010, background): “Consistently, increased expression of LOX and its related family members correlate clinically with tumor progression and elevated metastatic risk [27,28].”
Role of Extracellular Matrix in Development and Cancer Progression (2018, background): “Elevated LOX activity has been clinically associated with increased collagen cross-linking, fibrosis, and elevated risk of cancer metastasis [139].”
Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue (2009, background): “As such, another interesting candidate could be CTGF, which has been shown to be regulated in a fashion similar to that of LOX in the adipocyte (46).”
Reactive oxygen species in cancer (2010, background): “This leads to glycolytic ATP generation [202], reduced formation of mitochondriallygenerated H2O2, enhanced survival of poorly oxygenated cells and regulation of EMT- and metastasis-related genes [203].”