HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity.

By John D. Gordan, Jessica A. Bertout, Cheng-Jun Hu, J. Diehl, M. Simon. Cancer Cell, 2007

822 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/09aa3702872ff5c99acbe9f37b967545641205ee

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. M. C. Simon
2. C. V. Dang
3. G. Semenza
4. W. Kaelin
5. Craig B. Thompson
6. B. Keith
7. P. Ratcliffe
8. Amato J. Giaccia

In Molecular Biology

1. M. C. Simon
2. C. V. Dang
3. G. Semenza
4. W. Kaelin
5. Craig B. Thompson
6. P. Ratcliffe
7. B. Keith
8. B. Altman

Citations in the corpus

• MYC on the Path to Cancer (2012, background): “The ability of Myc or N-Myc to cooperate with HIF-1 could be highly relevant to the ability of cancer cells to survive and proliferate under moderately hypoxic conditions commonly found in the tumor microenvironment.”
• Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. (2016, background): “In contrast, HIF-2α can enhance c-Myc activity and promote cell cycle progression (Gordan et al., 2007a).”
• The Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells? (2015, neutral): “HIF-1a and HIF-2a, which promote cell cycle via c-Myc, represent a promising target for therapy for glioma patients (Gordan et al., 2007; Li et al., 2009).”
• MYC, Metabolism, and Cancer. (2015, background): “In contrast, HIF2α has been reported to promote MYC–MAX activity and therefore cooperates presumably with both endogenous and ectopic MYC (104).”
• The role of oxygen availability in embryonic development and stem cell function (2008, background): “, whereas HIF-2a has been shown to promote c-MYC-dependent proliferatio”
• The role of hypoxia-inducible factors in tumorigenesis (2008, background): “C-Myc promotes cellular proliferation by regulating the expression of genes involved in cell cycle control including cyclins (cyclin D2) and cyclin kinase inhibitors (p21 and p27).73 Unlike HIF-1, HIF-2 promotes C-Myc-dependent activation of cyclin D2 and repression of p27 in RCC cells.74 How HIF-2 ”
• Exploring the role of cancer stem cells in radioresistance (2008, background): “HIF2α also results in enhanced MYC transcriptional activit”