Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

By Todd R. Heallen, Min Zhang, Jun Wang, M. Bonilla-Claudio, E. Klysik, Randy L. Johnson, James F. Martin. Science, 2011

1,104 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2afd60d4aa90c08255a9a2c11e5eadfee9fc66e0

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Citations in the corpus

The Hippo signaling pathway in stem cell biology and cancer (2014, positive): “Loss of b-catenin in the Sav cKO hearts suppressed the overgrowth phenotype caused by Hippo pathway inactivation, suggesting that the Hippo pathway restrains cardiomyocyte proliferation and heart size by inhibiting Wnt signaling [118].”
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. (2015, positive): “Importantly, evenheterozygousdeletionofYapcompletely blocks liver tumorigenesis induced byNf2 knockout in mice, indicating that YAP activation is the major mechanism mediating the tumorigenic potential of Nf2mutations (Zhang et al., 2010).”
The biology of YAP/TAZ: hippo signaling and beyond. (2014, background): “Salvador/WW45, Mst1/2, and Lats2 inactivation in developing mouse hearts also caused severe heart enlargement (84, 188).”
YAP/TAZ at the roots of cancer (2016, background): “It is worth noting that genetic inactivation of Hippo pathway components in knockout mice is insufficient to trigger tumor formation in multiple tissues, such as mammary gland, lung, heart, kidney, pancreas and nervous system (Chen et al., 2014; George et al., 2012; Heallen et al., 2011; Lavado et a”
The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment (2013, neutral): “For example, while the MST kinases are essential to inhibit YAP and TAZ in the liver 135–138 , intestine 139 , pancreas 140, 141 , and heart 142 , they appear to be dispensable in the skin 106 .”
The Hippo Signaling Pathway in Development and Disease (2019, background): “Similar to the liver, targeted inactivation of Sav1, Mst1/2 or Lats2, or overexpression of YAP in the developing heart, increased cardiomyocyte proliferation and heart size (Heallen et al., 2011; von Gise et al., 2012; Xin et al., 2011).”
Mechanisms and pathways of growth failure in primordial dwarfism. (2011, background): “For instance, Wnt, TGF-b, Sonic Hedgehog (Shh), and Notch all impact on Hippo pathway activity (Alarcon et al. 2009; Varelas et al. 2010; Zhao et al. 2010; Heallen et al. 2011).”
Hippo pathway effector Yap promotes cardiac regeneration (2013, background): “In one study, embryonic cardiac deletion of Lats2 and Mst1/2, which function as negative regulators of Yap, resulted in excessive production of cardiomyocytes, which was been attributed to unrestrained activation of Yap (32).”
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal (2011, positive): “Recently, YAP was also shown to interact with β-catenin and induce expression of canonical Wnt target genes such as Sox2 and Snai2 in mouse heart tissu”
Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment (2013, background): “Likewise, conditional deletion of SAV1 led to enlarged hearts (23).”
The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease (2014, background): “Deletion of upstream Hippo pathway effectors, such as conditional deletion of Sav1 or Lats2 (Heallen et al., 2011), or induced expression of nuclear-localized S112A-Yap (vonGise et al.”
E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components (2011, background): “Recent studies have also shown that the Hippo signaling pathway restricts Wnt signaling either by TAZ interaction with DVL2 (41) or by inhibiting the interaction of YAP with β-catenin on target genes in the nucleus (42).”