The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

By Randy L. Johnson, G. Halder. Nature reviews. Drug discovery, 2013

871 citations recorded by the source corpus.

The Hippo signalling pathway is an emerging growth control and tumour suppressor pathway that regulates cell proliferation and stem cell functions. Defects in Hippo signalling and hyperactivation of its downstream effectors Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) contribute to the development of cancer, which suggests that pharmacological inhibition of YAP and TAZ activity may be an effective anticancer strategy. Conversely, YAP and TAZ can also have beneficial roles in stimulating tissue repair and regeneration following injury, so their activation may be therapeutically useful in these contexts. A complex network of intracellular and extracellular signalling pathways that modulate YAP and TAZ activities have recently been identified. Here, we review the regulation of the Hippo signalling pathway, its functions in normal homeostasis and disease, and recent progress in the identification of small-molecule pathway modulators.

Subfields: Cell Biology

View Paper: https://www.semanticscholar.org/paper/a9c0625d2acd7ff866bc26f40014d4fbdaabd806

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Citations in the corpus

• The Hippo signalling pathway and its implications in human health and diseases (2022, background): “357,358 At present, the development of potential drugs mainly focuses on three aspects of the Hippo pathway, including Hippo core kinase activity/expression, downstream YAP/TAZ expression levels and YAP/TAZ-TEAD interactions.”
• Emerging mechanisms and disease relevance of ferroptosis (2020, background): “In epithelial cancer cells, decreased E-cadherin or NF2 expression, reduced Hippo pathway activity, and enhanced YAP activation can promote epithelial–mesenchymal transition (EMT) and metastasis [87,88].”
• The Hippo signaling pathway in stem cell biology and cancer (2014, positive): “In general, the loss of Hippo signaling and/or the elevated YAP activity is associated with stem cell expansion in various organs [125,127].”