Dynamics of fat cell turnover in humans

By K. Spalding, E. Arner, P. Westermark, Samuel Bernard, B. Buchholz, O. Bergmann, L. Blomqvist, J. Hoffstedt, E. Näslund, Tom Britton and 5 more. Nature, 2008

2,355 citations recorded by the source corpus.

Subfields: Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/b4a14138a322bc667a9e06f89a7f68a5f5d9e333

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. B. Spiegelman
2. E. Rosen
3. André Tchernof
4. J. Despres
5. P. Seale
6. A. Chait
7. Laura J. den Hartigh
8. A. Mantovani

In Physiology

1. B. Spiegelman
2. E. Rosen
3. J. Kirkland
4. P. Seale
5. T. Tchkonia
6. J. Despres
7. A. Chait
8. Laura J. den Hartigh

Citations in the corpus

• Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications (2019, background): “Adipose tissue hyperplasia is considered as a “recovery mechanism” to overnutrition [42].”
• Endocrine disrupting chemicals: exposure, effects on human health, mechanism of action, models for testing and strategies for prevention (2019, background): “Obesogen exposure during pre- and early post-natal life can increase number of adipocytes permanently into adult life [135, 136].”
• Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders (2016, background): “reported that adipocyte numbers are roughly constant in lean and obese adults (74).”
• Dynamics of hippocampal neurogenesis in adult humans (2013, background): “Kempermann, G. (2012). New neurons for 'survival of the fittest'.”
• FTO Obesity Variant Circuitry and Adipocyte Browning in Humans (2015, background): “Risk allele carriers show reduced adipocyte differentiation marker PPARG2 (orange), indicating reduced adipocyte turnover.(25) IRX3 and IRX5 (black) are also shown as reference.”
• Metabolism Disrupting Chemicals and Metabolic Disorders (2016, positive): “In humans, adipose tissue develops by the 14 week of gestation [105] followed by a second period of increased cellularity that continues after birth and lasts through adolescence [106].”
• Mechanisms and Metabolic Implications of Regional Differences among Fat Depots (2013, background): “New fat cells appear throughout life (Spalding et al., 2008; Tchoukalova et al., 2010).”
• What We Talk About When We Talk About Fat (2014, positive): “More recently, stable isotope labeling from midcentury nuclear weapons testing was exploited to suggest that adipocyte number becomes fixed during childhood and early adulthood, with obese people achieving a higher ‘‘plateau’’ (Spalding et al., 2008).”
• Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. (2010, background): “However, recent studies find that the rate of adipocyte death is not increased in obese individuals (21).”
• Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth (2009, background): “Hyperplastic growth appears only at early stages in adipose tissue development [6,7].”
• Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling (2011, background): “In general, the turnover of adipose in subcutaneous and visceral fat is relatively slow (Ochi et al., 1988; Spalding et al., 2008).”
• Adipose Tissue Heterogeneity: Implication of depot differences in adipose tissue for Obesity Complications (2012, background): “6.2 Adipocyte death There are measurable rates of adipocyte death, although the rates are estimated to be similar in lean and obese (10 years) (Spalding et al. 2008).”
• Adult Neurogenesis in Humans. (2015, background): “Relating the measured genomic 14C concentration to atmospheric levels establishes the birth date of cells and their turnover dynamics (Spalding et al. 2005a, 2008; Bhardwaj et al. 2006; Bergmann et al. 2009).”