Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling

By E. Festa, Jackie A Fretz, Ryan Berry, Barbara A. Schmidt, Matthew S. Rodeheffer, M. Horowitz, V. Horsley. Cell, 2011

598 citations recorded by the source corpus.

In mammalian skin, multiple types of resident cells are required to create a functional tissue and support tissue homeostasis and regeneration. The cells that compose the epithelial stem cell niche for skin homeostasis and regeneration are not well defined. Here, we identify adipose precursor cells within the skin and demonstrate that their dynamic regeneration parallels the activation of skin stem cells. Functional analysis of adipocyte lineage cells in mice with defects in adipogenesis and in transplantation experiments revealed that intradermal adipocyte lineage cells are necessary and sufficient to drive follicular stem cell activation. Furthermore, we implicate PDGF expression by immature adipocyte cells in the regulation of follicular stem cell activity. These data highlight adipogenic cells as skin niche cells that positively regulate skin stem cell activity, and suggest that adipocyte lineage cells may alter epithelial stem cell function clinically.

Subfields: Genetics, Rehabilitation, Urology

View Paper: https://www.semanticscholar.org/paper/08c2b9f1b4fab024f595442c178a48d239006a32

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. P. Bonaldo
2. Rickard Sandberg
3. F. Gattazzo
4. V. Horsley
5. A. Urciuolo

In Rehabilitation

1. Nadia A. Rosenthal
2. J. Biernaskie
3. V. Horsley

In Urology

1. V. Horsley

Citations in the corpus

• The molecular anatomy of mouse skin during hair growth and rest (2019, background): “, & Fuchs, E. (2006). The hair cycle. Journal of Cell Science, 119(Pt 3), 391–393. Arwert, E. N., Hoste, E., & Watt, F. M. (2012). Epithelial stem cells, wound healing and cancer.”
• Fibroblasts: origins, definitions, and functions in health and disease (2021, background): “, 2008), whereas at the onset of new hair growth, dWAT stimulates DP fibroblast activity via PDGF ligands (Festa et al., 2011).”
• Extracellular matrix: A dynamic microenvironment for stem cell niche (2014, background): “dermal environment that surrounds the hair follicle [150–152].”
• What We Talk About When We Talk About Fat (2014, unknown): “Zfp423 expression in the developing adipocyte is repressed by the highly related factor Zfp521, which promotes osteogenesis and inhibits adipogenesis through interactions with Ebf1, another transcription factor required for early adipose commitment (Festa et al., 2011; Kang et al., 2012).”