Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo

By K. Jin, Yonghua Zhu, Yunjuan Sun, X. Mao, Lin Xie, D. Greenberg. Proceedings of the National Academy of Sciences of the United States of America, 2002

1,553 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b46dcfd6e94b43c26a99d654ce8cbf6a05133604

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Citations in the corpus

Environmental enrichment and neurogenesis: from mice to humans (2015, background): “or down-regulation of VEGF by RNA interference blocked the EE-induced neurogenesis [36 ,39].”
VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. (2003, positive): “Rat brain sections were processed for immunocytochemistry and doublelabel immunocytochemistry as described (26).”
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “VEGF also has neurogenic and neuroprotective effects (Jin et al., 2002; Schanzer et al., 2004; Storkebaum and Carmeliet, 2004; Storkebaum et al., 2004).”
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. (2006, background): “…forebrain neural stem cells and demonstrate that secreted factors from endothelial cells also promote neural stem cell proliferation (Cao et al., 2004; Fabel et al., 2003; Jin et al., 2002; Maurer et al., 2003; Schanzer et al., 2004; Shen et al., 2004; Yasuhara et al., 2004; Zhu et al., 2003).”
Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells (2006, background): “Other factors have also emerged as potentially important regulators of neurogenesis, most notably vascular endothelial growth factor (Jin et al. 2002) and BDNF (Zigova et al.”
Electroconvulsive seizure restores neurogenesis and hippocampus‐dependent fear memory after disruption by irradiation (2008, methodology): “…focus on VEGF and BDNF because expression of these factors is induced in the hippocampus by ECS (Nibuya et al., 1995; Newton et al., 2003), are progenitor cell mitogens (Pencea et al., 2001; Jin et al., 2002) and are implicated in neuronal survival (Storkebaum et al., 2004; Sairanen et al., 2005).”
Oxygen in stem cell biology: a critical component of the stem cell niche. (2010, background): “In a similar manner, VEGF expression is strongly upregulated by hypoxia, and increases adult neurogenesis (Jin et al., 2002; Shweiki et al., 1992).”
Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways (2006, background): “The effects were primarily to increase cell proliferation, and no alterations in cell survival were observed (Jin et al., 2002).”
Adult neurogenesis: from precursors to network and physiology. (2005, background): “24 g/day for 3 days concurrent with 2 50 mg · kg 1 · day 1 BrdU) stimulates cell proliferation in the rodent SVZ and SGZ by 7 days after treatment onset (241).”
Hippocampal neurogenesis: Opposing effects of stress and antidepressant treatment (2006, result): “We have also found that infusion of VEGF into the lateral ventricles increases neurogenesis in the hippocampus , consistent with a recent qualitative report (Jin et al., 2002).”