VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia.

By Yunjuan Sun, K. Jin, Lin Xie, Jocelyn T Childs, X. Mao, A. Logvinova, D. Greenberg. Journal of Clinical Investigation, 2003

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The potential of neural stem cells to repair stroke-induced brain damage (2009, background): “Some of the extensively studied growth factors after ischemia are IGF1 [1, 65, 142, 148], FGF2 [5, 126, 131, 144], EGF [40, 84, 126], VEGF [ 112 , 130, 149], erythropoietin [26], G-CSF [102, 104, 109], BDNF [101], GDNF [35] and MCP1 [143].”
Adult neurogenesis: from precursors to network and physiology. (2005, background): “54 g/day on days 1–3 of reperfusion concurrent with 2 50 mg · kg 1 · day 1 BrdU) increases the number of adult-born cells 1 mo (and not 3 days) after labeling, beyond the increase caused by ischemia (526).”
Persistent Production of Neurons from Adult Brain Stem Cells During Recovery after Stroke (2006, background): “... after extensive ischemic lesions [34], we found that spontaneous motor recovery after stroke affecting only the striatum occurred over several months concomitantly with striatal neurogenesis (Fig. 6). Also in line with a possible functional role of the new neurons, administration of molecules th”
Subventricular Zone-Derived Neuroblasts Migrate and Differentiate into Mature Neurons in the Post-Stroke Adult Striatum (2006, background): “, 2004), and insult-induced neurogenesis in the striatum is also reportedly influenced by blood vessels (Sun et al., 2003; Chen et al., 2005).”