Molecular Properties of Bacterial Multidrug Transporters

By M. Putman, H. V. van Veen, W. Konings. Microbiology and Molecular Biology Reviews, 2000

817 citations recorded by the source corpus.

Subfields: Molecular Biology, Molecular Medicine, Oncology

View Paper: https://www.semanticscholar.org/paper/b44cc0ddfeb55301d75a35555163571dcdfc27a5

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Citations in the corpus

Analysis of a Complete Library of Putative Drug Transporter Genes in Escherichia coli (2001, background): “All of these transporters possessing 14 hydrophobic regions have the glycine-rich motif (motif C) in transmembrane segment V that is conserved in the MF-type drug transporters (13, 42).”
Plasmid-Mediated Quinolone Resistance: a Multifaceted Threat (2009, background): “Numerous such mechanisms have been described, and they are increasingly being recognized as important determinants of antimicrobial resistance in a variety of organisms (160).”
Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria (2006, background): “ABC transporters have structural characteristics that differ from RND and MFS pump proteins, in that there are typically only six transmembrane-spanning regions (178).”
Structure, Function, and Evolution of Bacterial ATP-Binding Cassette Systems (2008, background): “The overwhelming majority of MDR efflux pumps identified and characterized to date are energized by proton motive force, and depending on their size, similarity in primary structure, and topology, they fall into one of four distinct transporter families (383), namely, the MFS (301), the SMR (small M”
The Transporter Classification Database (TCDB): recent advances (2015, background): “EMPT 3 GT 3 Holin I 1 (3) Holin II 4 Holin III 7 Holin IV 4 Holin V 2 Holin VI 2”
An overview of the antimicrobial resistance mechanisms of bacteria (2018, background): “The AcrB pump protein contains two binding pockets which allow the binding of substrates of varying size and chemical properties [28,29,52,73,74,79,82,88].”
Resistance-Nodulation-Cell Division-Type Efflux Pump Involved in Aminoglycoside Resistance in Acinetobacter baumannii Strain BM4454 (2001, background): “The secondary structure of RND-type efflux proteins was proposed to consist of 12 transmembrane segments (TMSs), with two long loops between TMSs 1 and 2 and TMSs 7 and 8 (27, 32).”
Stress responses in lactic acid bacteria (2002, background): “MDR efflux systems have been well studied in several Gram-positive bacteria including B. subtilis, S. pneumoniae and L. lactis (Putman et al. 2000) but the role of efflux in bile resistance has not yet been established.”