Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair.

By Qiang Xu, Yanshu Wang, Alain Dabdoub, P. Smallwood, John L. Williams, C. Woods, M. Kelley, Li Jiang, W. Tasman, Kang Zhang and 1 more. Cell, 2004

879 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b2e705565a70bfdac3a1c578cb206bc4e950cc73

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. R. Nusse
2. Hans Clevers
3. C. Logan

In Molecular Biology

1. Hans Clevers
2. R. Nusse
3. C. Logan
4. A. Prat
5. R. Daneman
6. Elaine Fuchs
7. C. Blanpain
8. S. Angers

Citations in the corpus

• The Wnt signaling pathway in development and disease. (2004, background): “Fzs are seventransmembrane receptors with a long N-terminal extension called a cysteine-rich domain (CRD).”
• Surrogate Wnt agonists that phenocopy canonical Wnt/β-catenin signaling (2017, neutral): “…Wnt ligands, and also the cysteine-knot growth factor norrin that also activates canonical Wnt signalling by FZD4 and LRP5/LRP6 oligomerization 29–31 , may possess intrinsic structural features that initiate additional or alternative signalling outcomes, such as by inducing ligand-specific…”
• The mouse retina as an angiogenesis model. (2010, background): “One example is Norrie’s disease, an inherited eye disease that is associated with persistent hyaloid vessels, incomplete development of the retinal vasculature, and pathologic retinal neovessel (NV) proliferation, often resulting in blindness from birth.(9) Besides developmental disorders, premature”
• The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength (2014, neutral): “Accordingly, Norrin would serve as a cognate ligand for Lgr4 in addition to its widely recognized interaction with the Frizzled4 receptor (Xu et al. 2004).”
• Wnt/β-catenin signaling and disease. (2012, neutral): “In addition, Norrin binds with high affinity and specificity to Frizzled-4, whereas coexpression of Norrin, Frizzled-4, and Lrp5 potently activates Wnt/b-catenin signaling (Xu et al., 2004).”
• Wnt/beta-catenin signaling in development and disease. (2006, neutral): “Embryos lacking Dwnt-5 resemble those lacking Derailed, that is, they generate aberrant neuronal projections across the midline (Yoshikawa et al., 2003).”
• Wnt/ b -Catenin Signaling, Disease, and Emerging Therapeutic Modalities (2017, background): “Norrin binds with high affinity and specificity to FZD-4 (Ke et al., 2013; Chang et al., 2015), while coexpression of Norrin, FZD-4, and LRP5 potently activates Wnt/b-catenin signaling (Xu et al., 2004).”
• The blood-brain barrier. (2015, background): “Loss of Norrin or Fzd4 produces major retinal vascular defects including a reduction in endothelial proliferation, vascular malformations, crossing of arteries and veins, a loss of venous fate, and leakiness of the blood– retinal barrier (Xu et al. 2004; Ye et al. 2010; Wang et al. 2012).”