Mechanisms of Antimicrobial Peptide Action and Resistance

By Michael R. Yeaman, N. Yount. Pharmacological Reviews, 2003

2,925 citations recorded by the source corpus.

Subfields: Emergency Medical Services, Immunology, Microbiology

View Paper: https://www.semanticscholar.org/paper/b2488e5a414bc33d77996977d6cca30be3c04ad6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Emergency Medical Services

In Immunology

In Microbiology

Citations in the corpus

Mechanisms of Cellular Uptake of Cell-Penetrating Peptides (2011, methodology): “AMPs also consist of short sequences of cationic and hydrophobic peptides [76, 77].”
Application of antimicrobial peptides in agriculture and food industry (2009, background): “developing proteolytic activities) strategies ( Yeaman and Yount 2003 ).”
Antimicrobial peptides: an overview of a promising class of therapeutics (2007, background): “Yet, this peptide is an efficient antimicrobial agent that causes membrane disruption due to a concentrated layer of peptide monomers on the surface [46, 52].”
CAMP: a useful resource for research on antimicrobial peptides (2009, background): “They generally act on structural components of the cell wall and can have multiple cellular targets (2).”
Antimicrobial Peptides: An Emerging Category of Therapeutic Agents (2016, background): “The fundamental differences between microbial and mammalian membranes protect mammalian cells against AMPs and enable selective action of these peptides (Yeaman and Yount, 2003).”
Antimicrobial Peptides (2013, background): “different stages of cell growth [237], and biofilm formation [229].”
Antimicrobial Peptides: Diversity, Mechanism of Action and Strategies to Improve the Activity and Biocompatibility In Vivo (2018, methodology): “Other features of the toroidal pore include ion selectivity and discrete size [69].”
From antimicrobial to anticancer peptides. A review (2013, background): “This points to the possibility of the same peptide to act by different mechanisms depending on the cell type in question (Yoo et al., 1997; Eliassen et al., 2006) and to be selective against determined types of cancer.”
Mechanisms and consequences of bacterial resistance to antimicrobial peptides. (2016, background): “The molecular basis of inducible AMP resistance has been reviewed extensively for both Gram-negative and Gram-positive bacteria (Anaya-Lopez et al., 2013; Gunn, 2001; Kraus and Peschel, 2006; Matamouros and Miller, 2015; Nawrocki et al., 2014; Nizet, 2006; Yeaman and Yount, 2003).”
Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations (2009, background): “Despite sharing a few common features (for example, cationicity, amphipathicity and short size), AMP sequences vary greatly, and at least four structural groups (α-helical, β-sheet, extended and looped) have been proposed to accommodate the diversity of the observed AMP conformation”
Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies (2006, background): “Indeed, the action of many peptides cannot be explained by disruption of membrane permeability barriers, as discussed in several review”
Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic-resistant superbugs. (2009, background): “It is important to note that peptides from each quartile had similar charge, hydrophobicity, and amphipathicity/ hydrophobic moment (Figure 2, panels a d), each of which have been considered to be critical determinants for the design of effective antimicrobial peptides (19, 25, 31).”