Antimicrobial Peptides: Diversity, Mechanism of Action and Strategies to Improve the Activity and Biocompatibility In Vivo

By Prashant Kumar, J. Kizhakkedathu, Suzana K. Straus. Biomolecules, 2018

1,010 citations recorded by the source corpus.

Antibiotic resistance is projected as one of the greatest threats to human health in the future and hence alternatives are being explored to combat resistance. Antimicrobial peptides (AMPs) have shown great promise, because use of AMPs leads bacteria to develop no or low resistance. In this review, we discuss the diversity, history and the various mechanisms of action of AMPs. Although many AMPs have reached clinical trials, to date not many have been approved by the US Food and Drug Administration (FDA) due to issues with toxicity, protease cleavage and short half-life. Some of the recent strategies developed to improve the activity and biocompatibility of AMPs, such as chemical modifications and the use of delivery systems, are also reviewed in this article.

Subfields: Microbiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/df67b3b4ec94607b6ee42187d04f19ed5c574bd6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Min Wang
2. Yue Ma
3. Zhengyan Guo
4. Na Tang
5. Xiaolin Liu
6. Yihua Chen
7. Yuwei Zhang
8. Binbin Xia

Citations in the corpus

• Identification of antimicrobial peptides from the human gut microbiome using deep learning (2022, result): “5), agreeing with previous findings of alpha-helix, pore-forming peptides among the most potent AMPs 21,54,55 .”