Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic-resistant superbugs.

By Artem Cherkasov, K. Hilpert, H. Jenssen, Christopher D. Fjell, Matthew Waldbrook, Sarah C. Mullaly, R. Volkmer, Robert E. W. Hancock. ACS Chemical Biology, 2009

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Designing antimicrobial peptides: form follows function (2011, methodology): “By replacing MIC values with such surrogate measures 148 , and combining these with highthroughput analysis and relatively inexpensive peptide array synthesis on cellulose sheets, a set of peptides with more than 1,400 distinct sequences was assayed for activity 149,150 .”
Multifunctional cationic host defence peptides and their clinical applications (2011, background): “Regarding cost of goods increasingly practical recombinant DNA expression strategies are starting to impact on cost of goods [7, 55]; furthermore, the use of peptide array and advanced computational strategies [ 13 ] and addition of fatty acyl chains have led to much smaller broad-spectrum peptides.”
Antimicrobial Peptides (2013, neutral): “against antibiotic-resistant superbugs [190].”