Neural stem cells and the origin of gliomas.

By N. Sanai, Arturo Alvarez-Buylla, M. Berger. New England Journal of Medicine, 2005

1,104 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b20c6fdee0535f9c636da84b97ebeb93d5e49073

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Citations in the corpus

Malignant astrocytic glioma: genetics, biology, and paths to treatment. (2007, background): “…of the “cell of origin” remains an area of active research for both hematological malignancies (Passegue et al. 2003) and solid tumors (Al-Hajj et al. 2003; Singh et al. 2004; Sanai et al. 2005; Taylor et al. 2005; Patrawala et al. 2006; Li et al. 2007; O’Brien et al. 2007; Prince et al. 2007).”
The biology of cancer stem cells. (2007, background): “The first report of neural stem cells in the context of tissue architecture showed that the subventricular zone (SVC) band in the human brain contains multipotent progenitor cells and these cells display characteristics similar to astrocytes (Sanai et al. 2004).”
A perivascular niche for brain tumor stem cells. (2007, background): “In the normal brain, neural stem cell niches are restricted to the hippocampus and subventricular zones where rates of cell proliferation are quite low (Sanai et al., 2005).”
Diffuse glioma growth: a guerilla war (2007, neutral): “can still be present [104, 152].”
The brain tumor microenvironment (2011, background): “This creates the somewhat paradoxical situation that a stem cell-related disease like glioblastoma (originating from mutant brain stem cells (Sanai et al., 2005)), occurs at a time when there are only very few stem cells left in the brain.”
Brain tumour stem cells (2006, background): “Interestingly, the subventricular zone seems to be present in the human adult brai”
Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient (2009, background): “In animal models, regions of the brain with stem cell populations are more sensitive to chemical or viral oncogenesis than areas with a low proportion of proliferating cells [25,26].”
The Glial Nature of Embryonic and Adult Neural Stem Cells (2009, background): “Although NSCs and some level of SVZ proliferation have been described in the human brain (Eriksson et al. 1998, Curtis et al. 2003, Sanai et al. 2005), the degree to which these cells generate new neurons and the extent of neuronal migration in the adult human brain remain controversial (Curtis et…”
Glioma cancer stem cells induce immunosuppressive macrophages/microglia. (2010, background): “Malignant gliomas contain glioma cancer stem cells (gCSCs) that are a heterogeneous population of multipotent undifferentiated cells with the capacity for selfrenewal and are able to form neurospheres that are nonadherent in vitro, are highly tumorigeneic,(23) and can recapitulate the characteristic”
An integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR and NF1 (2010, background): “Establishing the cell of origin ofGBMis critical for establishing effective treatment regimens (Sanai et al., 2005).”
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. (2006, background): “…stem cells (NSCs) and in situ glioma cells share the characteristics of continuous self-renewal, extensive brain parenchymal migration/infiltration, and potential for full or partial differentiation—properties not found in glioma cell lines (Morshead and van der Kooy, 2004; Sanai et al., 2005).”