Glioma cancer stem cells induce immunosuppressive macrophages/microglia.

By Adam Wu, Jun Wei, L. Kong, Yongtao Wang, W. Priebe, W. Qiao, R. Sawaya, A. Heimberger. Neuro-Oncology, 2010

656 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

The microenvironmental landscape of brain tumors (2017, background): “Given the robust effects of TAM inhibition on blocking gliomagenesis (Pyonteck et al., 2013), it is not surprising that activated TAMs have been shown to regulate glioma stem cell pools within the brain (Sarkar et al., 2014;Wu et al., 2010; Zhou et al., 2015).”
Macrophages in Tumor Microenvironments and the Progression of Tumors (2012, result): “In addition, M2 macrophages could induce T-cell anergy and therefore immunosuppression in agreement with what we mentioned previously [101].”
Targeting cancer stem cell pathways for cancer therapy (2020, background): “461 TAMs are closely related to glioma stem cell growth.”
Microglial cell origin and phenotypes in health and disease (2011, background): “TGFβ is known to inhibit microglial cell proliferation and production of pro-inflammatory cytokines in vitro”