Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells

By M. Haniffa, A. Shin, V. Bigley, N. McGovern, P. Teo, Peter See, Pavandip S. Wasan, Xiao-nong Wang, F. Malinarich, B. Malleret and 18 more. Immunity, 2012

740 citations recorded by the source corpus.

Summary Dendritic cell (DC)-mediated cross-presentation of exogenous antigens acquired in the periphery is critical for the initiation of CD8+ T cell responses. Several DC subsets are described in human tissues but migratory cross-presenting DCs have not been isolated, despite their potential importance in immunity to pathogens, vaccines, and tumors and tolerance to self. Here, we identified a CD141hi DC present in human interstitial dermis, liver, and lung that was distinct from the majority of CD1c+ and CD14+ tissue DCs and superior at cross-presenting soluble antigens. Cutaneous CD141hi DCs were closely related to blood CD141+ DCs, and migratory counterparts were found among skin-draining lymph node DCs. Comparative transcriptomic analysis with mouse showed tissue DC subsets to be conserved between species and permitted close alignment of human and mouse DC subsets. These studies inform the rational design of targeted immunotherapies and facilitate translation of mouse functional DC biology to the human setting.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/135af10df6f1af01c7ea309603a603d260ee2973

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In Immunology

1. Florent Ginhoux
2. K. Honda
3. E. Stanley
4. Shizuo Akira
5. R. Medzhitov
6. M. Guilliams

Citations in the corpus

• Critical Role for CD103+/CD141+ Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma (2016, neutral): “These DC have homologous populations in human tumors, which are defined by expression of CD141 (also known as BDCA3 [Haniffa et al., 2012]).”
• Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment (2019, background): “However, the expression of CD141 (BDCA-3, thrombomodulin), rather than αE, has been thought to mark human DC population functionally equivalent to mouse αE DCs (158).”
• IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses (2013, methodology): “…that a functionally-equivalent cross-presenting DC lineage is conserved in human peripheral tissues identifying the CD141hi DC subset with substantial cross-presenting capacities (Haniffa et al., 2012), similar to blood CD141+ DCs (Bachem et al., 2010; Crozat et al., 2010; Poulin et al., 2010).”
• Cancer immunotherapy via dendritic cells (2012, neutral): “Recent studies have further analyzed lymph-noderesident and skin-migratory DC subsets in the human [23, 46].”