Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo

By A. Cerwenka, J. Baron, L. Lanier. Proceedings of the National Academy of Sciences of the United States of America, 2001

680 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/b1b259852de0c9e851d3313e38b210c93056d78d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Steinle
2. I. Waldhauer
3. M. Smyth
4. N. Xiong
5. H. Yagita
6. K. Takeda
7. Y. Hayakawa
8. D. Raulet

In Oncology

1. A. Steinle
2. I. Waldhauer
3. Y. Hayakawa
4. M. Smyth
5. K. Takeda
6. D. Raulet
7. N. Xiong

Citations in the corpus

• Functions of natural killer cells (2008, neutral): “) or the upregulation of NKG2D ligands (for example, H60, Rae1β, Rae1δ, Rae1γ, Mult-1”
• NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy. (2008, background): “Transfected tumor cell lines expressing NKG2D ligands are rejected in vivo in an NKG2D-dependent fashion (Cerwenka et al., 2001; Diefenbach et al., 2001).”
• Cutting Edge: Down-Regulation of MICA on Human Tumors by Proteolytic Shedding (2002, background): “In fact, two recent reports described that tumor cells highly expressing NKG2DL were rejected by NK cells and CD8 T cells and stimulated tumor immunity against the parental cell lines in a mouse model (16, 22).”
• Roles of the NKG2D immunoreceptor and its ligands (2003, result): “Similar results were obtained with the RMA cell line, which is also highly tumorigeni”
• New aspects of natural-killer-cell surveillance and therapy of cancer (2002, background): “Ectopic expression of the Rae-1β or H60 in several tumour cell lines resulted in potent NK-cell- and CD8 + T-cell-mediated rejection of MHC class I high and class I low tumour cells by syngeneic mic”
• NK cells and cancer immunosurveillance (2008, background): “In vivo experiments assessing a functional role of NKG2DL for tumour surveillance demonstrated that ectopic expression of Rae1b and H60 conferred a strong immunostimulatory capacity to otherwise tumour-forming malignant cell lines (Cerwenka et al., 2001; Diefenbach et al., 2001).”