How matrix metalloproteinases regulate cell behavior.

By M. Sternlicht, Zena Werb. Annual Review of Cell and Developmental Biology, 2001

4,072 citations recorded by the source corpus.

Subfields: Cancer Research, Hematology, Oncology

View Paper: https://www.semanticscholar.org/paper/b19e6e9bb418438d26326335d6c791d973222cec

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Citations in the corpus

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. (2009, background): “MMP-3, which is upregulated in many breast cancers [149], also mediates CI in cultured cells and in transgenic mice [150,151].”
Axis of evil: molecular mechanisms of cancer metastasis (2003, neutral): “For nomenclature, classification, domain structure, and biological functions of MMPs, we refer to excellent recent reviews (Brew et al., 2000; Sternlicht and Werb, 2001; Egeblad and Werb, 2002).”
Regulation of matrix metalloproteinases: An overview (2003, background): “Thus, MMPs are tightly regulated by different mechanisms during virtually every aspect of their life span, from their induction to their ultimate destruction [25].”
Matrix metalloproteinases as modulators of inflammation and innate immunity (2004, background): “In vitro studies have shown considerable overlap in the substrates that MMPs can cleave, particularly among the extracellular-matrix (ECM) substrate”
The matrix metalloproteinase system: changes, regulation, and impact throughout the ovarian and uterine reproductive cycle. (2003, background): “Sternlicht and Werb (8) have summarized the nonmalignant phenotypes associated with the genetic modifications of nine of the various MMPs (e.”
Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development (2003, background): “MMPs, which comprise a large family of enzymes with differential abilities to degrade specific ECM components, play a vital role in this process (Sternlicht and Werb, 2001).”
Control of matrix metalloproteinase catalytic activity. (2007, background): “Compartmentalization In vitro studies have demonstrated significant overlap in the substrates MMPs can cleave, particularly among the extracellular matrix (ECM) substrates (Sternlicht and Werb, 2001).”
Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture. (2005, background): “The ability of the gelatinases, MMP-2 and -9, to activate TGF-␤ (306) could feed forward to promote matrix protein synthesis after FIG.”
Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion (2007, background): “Multiple sets of proteolytic enzymes, including matrix metalloproteinases (MMP) and serine and cysteine proteases, are upregulated and activated during cancer progressio”
Molecular mechanisms of glioma invasiveness: the role of proteases (2003, background): “cgi?l=21857">Timp1 or lack Mmp9 develop fewer cancers than mice that overexpress Mmp9 (Ref”
Compensation mechanism in tumor cell migration (2003, background): “Proteases further control cell adhesion, cytoskeletal organization, and the release of soluble factors ( Sternlicht and Werb, 2001; and references therein).”