Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development

By S. Ivkovic, B. Yoon, S. Popoff, F. Safadi, Diana E. Libuda, R. Stephenson, A. Daluiski, K. Lyons. Development, 2003

730 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/def11b8d99eff9e69e85f4b56d8f0f17c00cf2be

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In Molecular Biology

1. David J. Abraham
2. Brandon S. Gaut
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4. A. Leask
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7. R. Oreffo
8. J. Campisi

Citations in the corpus

• All in the CCN family: essential matricellular signaling modulators emerge from the bunker (2006, background): “These mice exhibit impaired chondrocyte proliferation and proteoglycan production within the hypertrophic zone (Ivkovic et al., 2003).”
• Developmental Patterns in Mesozoic Evolution of Mammal Ears (2012, background): “…network includes Transforming growth factor-ß (Tgf-ß) and its receptor (Ito et al. 2002, Oka et al. 2007), Connective tissue growth factor (Ctgf ) (Ivkovic et al. 2003), Fibroblast growth factor (Fgf ) (Tucker et al. 2004), Epidermal growth factor (Egf ) (Shum et al. 1993), and Bone…”
• Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets (2011, background): “Ccn2 -null mice are perinatal lethal owing to respiratory defects that occur as a secondary consequence of severe skeletal malformation”
• TGF‐β signaling and the fibrotic response (2004, background): “Mice heterozygous for a deletion for the CTGF gene die immediately after birth due at least in part to defects on matrix organization and synthesis during osteogenesis, resulting in a major defect in the development of the skeletal component of the rib cage (114).”
• Osteogenesis and angiogenesis: the potential for engineering bone. (2008, background): “…Growth Factor (aFGF), basic Fibroblast Growth Factor (bFGF) and, Type X collagen, MMP13 and alkaline phosphatase (Baron et al., 1994; Nagai and Aoki, 2002; Gerber et al., 1999; Horner et al., 1999; Carlevaro et al., 2000; Maes et al., 2002; Alini et al., 1994; Ivkovic et al., 2003; Väänänen, 1980).”