Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture.

By A. Newby. Physiological Reviews, 2005

854 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/50681866aa9e9cd3e777c95543b9c10d9cab393e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. R. Khalil
2. Gillian Murphy
3. Hideaki Nagase
4. Xi Wang
5. G. Boden
6. R. Visse
7. K. Woollard
8. A. Tedgui

In Molecular Biology

1. Gillian Murphy
2. R. Khalil
3. Hideaki Nagase
4. Xi Wang
5. G. Boden
6. R. Visse
7. K. Woollard
8. A. Tedgui

In Oncology

1. R. Khalil
2. Hideaki Nagase
3. Gillian Murphy
4. Xi Wang
5. K. Woollard
6. G. Boden
7. R. Visse
8. A. Tedgui

Citations in the corpus

• Obesity and Free Fatty Acids (FFA) (2008, background): “As mentioned previously, FFAs also promote the release of proinflammatory cytokines, which are known to be potent stimulators of MMP synthesis and release [49].”
• Molecular Mechanisms of Dermal Aging and Antiaging Approaches (2019, background): “In the skin, the major source of MMPs are epidermal keratinocytes and dermal fibroblasts, although MMPs can also be produced by endothelial cells and immunocytes [22,23].”
• Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease. (2018, background): “However, MMP-9 knockout is not associated with decreased VSMC proliferation in mouse model of carotid artery occlusion (Galis et al., 2002), likely due to compensatory activation of other proteases (Newby, 2005).”
• Structure and function of matrix metalloproteinases and TIMPs. (2006, positive): “…such as arthritis, nephritis, cancer, encephalomyelitis, chronic ulcers, fibrosis, etc. Uncontrolled ECM remodelling of the myocardium and vasculature are features of cardiovascular disorders such as atherosclerosis, stenosis, left ventricular hypertrophy, heart failure, and aneurysm [1–3].”
• Monocytes in atherosclerosis: subsets and functions (2010, background): “Over time, the secretion of matrix-degrading proteases and cytokines by macrophages can cause the fibrous cap that prevents contact between the blood and prothrombotic material in the plaque to thin”
• Macrophage polarization: An opportunity for improved outcomes in biomaterials and regenerative medicine (2012, neutral): “plaques, potentially leading to thromboembolism [56].”
• Engineering Complex Tissues (2006, neutral): “The VIC synthesize the valvular ECM molecules and express matrix degrading enzymes such as matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) that mediate ECM remodeling and repair.(149) In normal valves, VIC are fibroblast-like (i.”
• Cytokines in atherosclerosis: pathogenic and regulatory pathways. (2006, background): “207, 251, 707) Oxidation of LDL (induction cell oxidant stress) (204, 458) Stimulation of MMP expression (500) Modulation of extracellular matrix expression (17) Modulation of endothelial of SMC progenitor differentiation (370, 389,”
• Matrix metalloproteinase-9: Many shades of function in cardiovascular disease. (2013, background): “MMP-9 plays divergent roles in the formation and destabilization of atherosclerotic plaques (FIGURE 6A) (80).”
• Progress in matrix metalloproteinase research. (2008, background): “Remodelling also occurs during the course of diseases such as arthritis, cancer and cardiovascular disease, in part in an attempt at repair, but is frequently dysregulated and destructive (Milner and Cawston, 2005; Newby, 2005; Sternlicht and Werb, 2001; Burrage and Brinckerhoff, 2007).”