Immunological and inflammatory functions of the interleukin-1 family.

By C. A. Dinarello. Annual Review of Immunology, 2009

3,567 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b15b1d56336617bbeb383cf0d73fd6da2512e07f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. M. Lamkanfi
2. G. Núñez
3. E. Latz
4. Shizuo Akira
5. V. Dixit
6. Peter Libby
7. P. Ridker
8. Katherine A. Fitzgerald

In Molecular Biology

1. M. Lamkanfi
2. G. Núñez
3. V. Dixit
4. E. Latz
5. T. Kanneganti
6. Yuan He
7. Katherine A. Fitzgerald
8. J. Tschopp

Citations in the corpus

• IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice. (2012, background): “Although Casp-1 cleaves IL-1β, IL-18, and IL-33 (8), and IL-1R1 recognizes IL-1α, IL-1β, and IL-1Ra (16), our study provides several lines of evidence that IL-1β — not IL-18, IL-33, or IL-1α — is the primary cytokine that mediates the pathogenic effects of activated inflammasome in ALD.”
• Canonical Nlrp3 inflammasome links systemic low grade inflammation to functional decline in aging (2013, neutral): “Depending on the disease model, several redundant upstream mechanisms control the processing and secretion of mature IL-1b; these include neutrophil-derived serine proteinase 3 and granzyme A (Dinarello, 2009).”
• The sterile inflammatory response (2010, background): “IL-1β is a potent multifunctional proinflammatory cytokine, whose activity is controlled at the transcriptional, translational, maturation and secretion levels (64).”
• Mechanisms and functions of inflammasomes. (2014, background): “IL-18 is important for IL-17 expression by Th17 cells and may polarize T cells toward Th1 or Th2 profiles in combination with other cytokines (Dinarello, 2009).”
• Interleukin-1 (IL-1) Pathway (2010, background): “The occurrence of severe multiorgan inflammation in patients with homozygous mutations or deletions of the gene encoding interleukin-1 receptor antagonist (IL-1RA) (7, 8) and the successful blockade of inflammatory reactions in humans by application of recombinant IL-1RA (5) or antibodies to IL-1β (”
• Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector? (2015, neutral): “As mentioned earlier, these mechanisms may potentially include other downstream targets of caspase-1 independent of IL-1 b or IL-18, such as pyroptosis, inhibition of glycolysis, noninflammatory cell death, and activation of lipid biogenesis pathways (49, 65, 90, 115).”
• The Role of Markers of Inflammation in Traumatic Brain Injury (2013, background): “The IL-1 family includes the closely related agonists IL-1α and IL-1β, the antagonist IL-1ra, and the other family member, the agonist IL-18 (Dinarello, 1994, 1998, 2009; Barksby et al., 2007).”
• Human Monocytes Engage an Alternative Inflammasome Pathway. (2016, neutral): “…production is associated with monogenetic auto-inflammatory diseases (Masters et al., 2009), but also with ligand-dependent, multifactorial, sterile inflammatory conditions, such as atherosclerosis, type 2 diabetes, Alzheimer’s disease, or gout (Dinarello, 2009, 2011; Haneklaus and O’Neill, 2015).”
• Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. (2012, background): “Secretion of interleukin-1b (IL-1b), a potent pyrogen that elicits a strong proinflammatory response (Dinarello, 2009), is tightly controlled by a diverse class of cytosolic complexes known as the inflammasome (Latz, 2010).”
• Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters. (2018, neutral): “IL-1β also prompts vasodilation, and increases expression of adhesion molecules in the endothelium, which promotes infiltration of immune cells into affected tissue (Dinarello, 2009).”
• Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. (2014, background): “[50] Dinarello CA.”
• Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease. (2014, background): “It is also important in the secretion of acute phase proteins by the liver [48], which it does in cooperation with IL-1 [6].”
• NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis. (2018, background): “Mature caspase-1 has a very short half-life37 and is therefore not well suited for the extracellular maturation of pro–IL-1β.”
• The NALP3/NLRP3 Inflammasome Instigates Obesity-Induced Autoinflammation and Insulin Resistance (2011, background): “The release of bioactive IL-1β and IL-18 from macrophages is in turn dependent on autocatalytic activation of procaspase-1 zymogen into enzymatically active 10-kDa and 20-kDa caspase-1 heterodimer”
• The role of inflammation in epilepsy (2010, neutral): “…mechanisms include production of proteins that compete with cytokines to bind their receptors, such as IL-1 receptor antagonist protein (IL-1ra), 41 and decoy receptors that bind cytokines and chemokines but are incapable of signaling, thereby acting as molecular traps to prevent such ligands…”