Interleukin-1 (IL-1) Pathway

By A. Weber, P. Wasiliew, M. Kracht. Science Signaling, 2010

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The role of glia in the spinal cord in neuropathic and inflammatory pain. (2015, background): “Similarly, IL-1R2 is able to bind IL-1β with comparable affinity to IL-1R1 but lacks the appropriate cytosolic region to activate downstream signalling proteins (Weber et al. 2010; Dunn et al. 2001).”
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. (2011, background): “(8) Efflux of potassium from the cell after ATP binding to P2X7 receptor.”
Interleukin-18 and IL-18 Binding Protein (2013, background): “Following the formation of the heterodimer, the Toll-IL-1 receptor (TIR) domains approximate and it appears that the cascade of sequential recruitment of MyD88, the four IRAKs and TRAF-6 followed by the degradation of IκB and release of NFκB are nearly identical as that for IL-1 (14).”