Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
By K. Shimada, T. Crother, J. Karlin, J. Dagvadorj, N. Chiba, Shuang Chen, V. K. Ramanujan, Andrea J. Wolf, L. Vergnes, D. Ojcius and 8 more. Immunity, 2012
2,083 citations recorded by the source corpus.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/92c715a162d8d4ffe7135e9e7569905a765660ca
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In Immunology
- T. Kanneganti
- M. Lamkanfi
- J. Zindel
- Navdeep S. Chandel
- P. Kubes
- V. Dixit
- G. Núñez
- Claudio Franceschi
In Molecular Biology
Citations in the corpus
- NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases (2015, background): “This is an open access article u adipose tissue macrophages; ATP, domain; CARD, caspase recruitmen drome; CPPD, calcium pyrophosph nflammatory syndrome; FCU, fami eptide; IL-1β, Interleukin-1β; IL-1 R ceptor; MDP, muramyl dipeptide; main; NLRP3, nucleotide-binding atal-onset multisystem inflammato…”
- Mechanisms and functions of inflammasomes. (2014, background): “…production of mitochondrial reactive oxygen species (Zhou et al., 2011), (4) the release of mitochondrial DNA or the mitochondrial phospholipid cardiolipin (Iyer et al., 2013; Nakahira et al., 2011; Shimada et al., 2012), and (5) the cytosolic release of lysosomal cathepsins (Hornung et al., 2008).”
- Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance (2021, background): “Moreover, mtROS can also induce renal injury by activating proinflammatory signals such as Toll-like receptors (TLRs) and the NLRP3 inflammasome [17,18].”
- The adapter MAVS promotes NLRP3 mitochondrial localization and inflammasome activation (2013, positive): “Some studies implicate mitochondria as the cellular source of ROS and oxidized DNA required for NLRP3 activation (Nakahira et al., 2011; Shimada et al., 2012; Zhou et al., 2011); others indicate that ROS production is required for priming and transcriptional induction of NLRP3 expression, but not fo”
- Inflammaging and 'Garb-aging'. (2017, background): “mtDNA, when oxidized and released into the cytosol, can also be recognized by NLRP3 inflammasomes, leading to Il-1 maturation and release [55].”