Human Monocytes Engage an Alternative Inflammasome Pathway.

By Moritz M. Gaidt, Thomas Ebert, Dhruv Chauhan, Tobias Schmidt, Jonathan L. Schmid-Burgk, F. Rapino, A. Robertson, Matthew A Cooper, Thomas Graf, V. Hornung. Immunity, 2016

728 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/463665bfd8d395f1b120d754cd46cb7388c723be

Citations in the corpus

• Inflammation and atherosclerosis: signaling pathways and therapeutic intervention (2022, neutral): “In addition, the NLRP3 inflammasome is also activated by LPS via an alternative pathway that does not require K efflux, ASC speckle formation, or pyroptosis, which was only found in human monocytes.(170)”
• The pore forming protein gasdermin D regulates interleukin-1 secretion from living macrophages (2017, neutral): “Bacterial lipopolysaccharides (LPS) induce inflammasome-mediated release of IL-1 from living humanmonocytes (Gaidt et al., 2016), and living neutrophils also release IL-1 (Chen et al., 2014).”
• The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation (2019, neutral): “The alternative inflammasome pathway does not require K+ efflux, induce ASC speck formation, or lead to subsequent pyroptosis [135].”
• The P2X7 Receptor in Infection and Inflammation (2017, neutral): “Recently, an alternative route not involving the classical ‘‘second signal’’ and the cytosolic K+ drop has been described in LPS-stimulated human monocytes by Hornung and coworkers (Gaidt et al., 2016).”
• TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling (2020, neutral): “While it ultimately leads to IL-1β secretion, no concomitant pyroptosis of monocytes occurs [115].”
• The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation (2016, neutral): “…et al., 2008), dendritic cells (Edgeworth et al., 2002), enterocytes (Sellin et al., 2014), and hematopoietic progenitors (Masters et al., 2012), whereas neutrophils and monocytes do not undergo pyroptosis after inflammasome activation (Miao et al., 2010a; Chen et al., 2014; Gaidt et al., 2016).”
• Caspases in cell death, inflammation and disease (2019, neutral): “Although several mechanisms of IL-1β secretion from viable cells have recently been reported (Evavold et al., 2018; Gaidt et al., 2016), pyroptosis and necroptosis are rapidly emerging as the prime mechanisms for secretion of IL-1β and IL-18, as well as DAMPs such as ATP, HMGB1, S100 proteins and IL”