Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

By K. Flurkey, J. Papaconstantinou, Richard A. Miller, D. Harrison. Proceedings of the National Academy of Sciences of the United States of America, 2001

799 citations recorded by the source corpus.

Subfields: Aging, Pediatrics, Perinatology and Child Health, Physiology

View Paper: https://www.semanticscholar.org/paper/b111be1805b245b8dca24669ac379f7419f666a5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. Brian K. Kennedy
2. J. Speakman
3. Nicholas A. Bishop
4. Matt Kaeberlein
5. Tao Lu
6. E. Masoro
7. B. Yankner
8. J. Campisi

In Pediatrics, Perinatology and Child Health

1. J. Speakman

In Physiology

1. Matt Kaeberlein
2. Nicholas A. Bishop
3. J. Speakman
4. Brian K. Kennedy
5. Tao Lu
6. B. Yankner
7. Mark P. Mattson
8. V. Longo

Citations in the corpus

• Neural mechanisms of ageing and cognitive decline (2010, background): “In mice, reducing the growth hormone signalling from the hypothalamic–pituitary axis extends lifespa”
• Modulation of mammalian life span by the short isoform of p53. (2004, background): “The Ames and Snell GH-deficient mice have significantly longer life spans and exhibit significant delays in biological senescence compared to wild-type mice (Flurkey et al. 2001), and recent studies show that reduced levels of the IGF-1 (Holzenberger et al.”
• IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice (2003, neutral): “The long-lived Prop1 df/df (Ames dwarf) and Pit1 dw/dw (Snell dwarf) mutant”
• Extension of chronological life span in yeast by decreased TOR pathway signaling. (2006, background): “Article and publication are at http://www.genesdev.org/cgi/doi/10.1101/ gad.1381406. in insulin-like signaling can extend mammalian life span (Brown-Borg et al. 1996; Coschigano et al. 2000; Flurkey et al. 2001, 2002; Bluher et al. 2003; Holzenberger et al. 2003).”
• Body size, energy metabolism and lifespan (2005, background): “These effects appear to be homologous in both Drosophila and mice (Tatar, 1999; Coschigano et al., 2000; Flurkey et al., 2001, 2002; Bartke, 2001; Hsieh et al., 2002a,b; Tatar et al., 2003; Brown-Borg, 2003).”
• Insulin-like growth factors and neoplasia (2004, background): “and also have a longer life expectancy than control”
• Trends in oxidative aging theories. (2007, background): “There are only two interventions consistently reported to increase life span in laboratory mice: caloric restriction [165] and modulation of the anabolic GH/IGF-1 axis [64,65,166,167].”
• Overview of caloric restriction and ageing. (2005, background): “The possible significance of this finding was not recognized until some years later when the Ames and Snell Dwarf mice were found to exhibit life extension (Brown-Borg et al., 1996; Bartke et al., 2001; Flurkey et al., 2001).”