Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1.

By Eric V. Dang, J. Barbi, Huang-Yu Yang, Dilini Jinasena, Hong-gang Yu, Ying Zheng, Zachary Bordman, Juan Fu, Y. Kim, Hung-Rong Yen and 8 more. Cell, 2011

1,473 citations recorded by the source corpus.

Subfields: Cancer Research, Endocrine and Autonomic Systems, Genetics

View Paper: https://www.semanticscholar.org/paper/b03effa15131ae7079f742a20477f1f702e34b64

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In Cancer Research

1. Michael D. Buck
2. Navdeep S. Chandel
3. Erika L. Pearce
4. S. Kaech
5. R. Sowell
6. F. Quintana
7. J. Espinosa
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In Endocrine and Autonomic Systems

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In Genetics

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2. Cristina Gutiérrez-Vázquez
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Citations in the corpus

• Regulation of the immune response by the aryl hydrocarbon receptor (2018, background): “These effects of HIF1a and AHR on cellular metabolism may contribute to the role of these transcription factors in the differentiation of other T cell types such as Th17 cells (Dang et al., 2011; Shi et al., 2011).”
• Transcriptional Regulation by Hypoxia Inducible Factors (2013, background): “Dang et al. have recently reported that HIF1A can also act as a coactivator for RORgt, an important regulator of proinflammatory TH17 cells, and is important for increased expression of key genes under hypoxic conditions (Dang et al., 2011).”
• HIF Transcription Factors, Inflammation, and Immunity (2014, neutral): “…of HIF-1a mRNA and protein, especially in the proinflammatory T helper 17 (Th17) CD4 + T cell lineage, by a mechanism dependent on STAT3 (Dang et al., 2011; Ikejiri et al., 2012; Nakamura et al., 2005; Shi et al., 2011; Wang et al., 2014), where IL-6 and transforming growth factor-b…”
• Metabolic Instruction of Immunity (2017, positive): “Dampening glycolysis through deletion of HIF-1α or with the inhibitor 2-DG in T cells impairs Th17 development and instead promotes Treg cells, even under Th17-inducing culture conditions (Dang et al., 2011; Shi et al., 2011).”
• Metabolic Regulation of T Lymphocytes (2013, background): “HIF-1α can also bind the Treg-determining transcription factor Foxp3, leading to Foxp3 degradation (90).”
• Development and maintenance of regulatory T cells. (2013, background): “For example, hypoxia-inducible factor 1 (HIF-1), a key metabolic sensor, regulates the balance between Treg and Th17 cell differentiation (Dang et al., 2011).”
• Hypoxia-Inducible Factors in Physiology and Medicine (2012, neutral): “…production of cartilage) (Schipani et al., 2001), adipogenesis (Yun et al., 2002), B lymphocyte development (Kojima et al., 2002), osteogenesis (Wang et al., 2007), hematopoiesis (Takubo et al., 2010), T lymphocyte differentiation (Dang et al., 2011), and innate immunity (Zinkernagel et al., 2007).”
• Fueling Immunity: Insights into Metabolism and Lymphocyte Function (2013, neutral): “TH17 cell development is promoted by hypoxia inducible factor–1a (HIF-1a) (35, 36), an oxygen-sensitive transcription factor that regulates glycolytic gene expression in TH17 cells.”