Metabolic Instruction of Immunity
By Michael D. Buck, R. Sowell, S. Kaech, Erika L. Pearce. Cell, 2017
1,054 citations recorded by the source corpus.
Choices have consequences. Immune cells survey and migrate throughout the body and sometimes take residence in niche environments with distinct communities of cells, extracellular matrix, and nutrients that may differ from those in which they matured. Imbedded in immune cell physiology are metabolic pathways and metabolites that not only provide energy and substrates for growth and survival, but also instruct effector functions, differentiation, and gene expression. This review of immunometabolism will reference the most recent literature to cover the choices that environments impose on the metabolism and function of immune cells and highlight their consequences during homeostasis and disease.
Subfields: Endocrinology, Diabetes and Metabolism, Genetics, Physiology
View Paper: https://www.semanticscholar.org/paper/e56edd2a06e487bb51a80362f3f12afd5cf710a5
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Endocrinology, Diabetes and Metabolism
In Genetics
In Physiology
Citations in the corpus
- Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes? (2018, background): “Not only do the quiescent and activated states have different metabolic requirements but also the differentiation of the various subtypes of T cells is dependent on the specific metabolic pathways used (88).”
- CD8+ T cells regulate tumor ferroptosis during cancer immunotherapy (2019, background): “Tumor metabolism contributes to immune evasion via inducing T cell dysfunction and exclusion 24,25 .”
- Tumor microenvironment complexity and therapeutic implications at a glance (2020, background): “Since antitumor immunity suppression is progressively tied to key metabolic pathways' activities and intratumoral metabolite levels in immune cells [227] , the way by which CAF secretome could affect metabolism and immune cells function in the TME requires further investigation [228] .”
- Targeting Metabolism for Cancer Therapy (2017, background): “Determining how immune cell metabolism interacts with tumor metabolism, and how this is modulated by drugs targeting metabolic enzymes, might aid in the design of more effective immunotherapies (Buck et al., 2017; Mockler et al., 2014).”
- Mitochondrial metabolism and cancer (2017, background): “On the other hand, mitochondrial metabolism is involved in many functions linked to anticancer immunity, including (but not limited to) inflammasome activation, the establishment of protective immunological memory as well as the differentiation and tumoricidal activity of specific macrophage subsets”