Kinetic Modeling of Amyloid Binding in Humans using PET Imaging and Pittsburgh Compound-B

By J. Price, William E. Klunk, B. Lopresti, Xueling Lu, Jessica A. Hoge, S. Ziolko, D. Holt, C. Meltzer, Steven DeKosky, Chester A. Mathis. Journal of Cerebral Blood Flow and Metabolism, 2005

718 citations recorded by the source corpus.

Subfields: Neurology, Physiology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/b020836a39a5813413d0e65c79a2cf342e2776b9

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Citations in the corpus

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies. (2013, background): “…three categories: (1) CSF Ab detection and cerebral PiB-PET examination reflecting abnormal amyloid metabolism in AD brains (Palmert et al., 1990; Price et al., 2005; Rosenmann, 2012), (2) CSF tau detection and structural MR imaging reflecting neurodegeneration (Rosenmann, 2012; Vigo- Pelfrey et…”
Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease (2017, methodology): “Distribution volume ratios (DVRs) for PiB images were generated with Logan graphical analysis on PiB frames corresponding to 35– 90 min post-injection using a cerebellar gray matter reference region (Logan et al., 1996; Price et al., 2005).”
11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment. (2008, result): “While the proportion of PiB negative aMCI subjects in our study may be higher than seen in other studies, perhaps due to the older ages in our study, observing PiB negative aMCI subjects is consistent with results from other studies (Lopresti et al., 2005; Pike et al., 2007; Price et al., 2005; Rowe”
The Centiloid Project: Standardizing Quantitative Amyloid Plaque Estimation by PET (2014, positive): “Magnetic resonance imaging (MRI) was performed at either 1.5T or 3T using previously published methods [7; 14; 15; 20].”
Two-year follow-up of amyloid deposition in patients with Alzheimer's disease. (2006, methodology): “The mean absolute percentage difference [Mean abs (%Diff)] was calculated for all four patients, yielding an interval of expected variance in the analysis of PIB retention (Price et al., 2005).”
β-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease (2007, methodology): “The cerebellar cortex was used as a reference region as it is relatively devoid of senile plaques and shows no PIB binding in controls or AD (Price et al., 2005; Rowe et al., 2007).”
Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly (2008, neutral): “Participants with MCI who also had significant PiB retention typically show a much higher amount of PiB retention than cognitively unimpaired elderly persons, in the range of AD participants.(16,40) Most participants with MCI show a dichotomous pattern: 30% to 40% are clearly amyloid-negative, and 5”
Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease (2009, methodology): “The Logan method was used on a regional basis to characterize and compare PiB DVRs in preselected ROIs and on a voxel-by-voxel basis to generate PiB DVR images and statistical maps (6, 8, 39).”
Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease (2008, methodology): “…Alzheimer’s disease patients have 2- to 3-fold greater PiB retention on PET scans in brain areas known to have high amounts of fibrillar (i.e. Congo red and thioflavin-S labelled) Ab plaques in Alzheimer’s disease, such as frontal cortex and temporal lobe (Klunk et al., 2004; Price et al., 2005).”
Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. (2009, methodology): “DVRs for PIB images were created using Logan graphical analysis with frames corresponding to 35–90 min post-injection (Logan et al., 1996; Price et al., 2005).”
PET Imaging of Tau Deposition in the Aging Human Brain (2016, neutral): “Distribution volume ratios (DVRs) for PiB images were created using Logan graphical analysis (35–90 min postinjection) and a gray matter masked cerebellum reference region (Logan et al., 1996; Price et al., 2005).”
Amyloid deposition is associated with impaired default network function in older persons without dementia (2009, methodology): “graphical analysis method with cerebellar cortex as the reference tissue input function, was used to evaluate specific PiB retention expressed as the distribution volume ratio (DVR) (Price et al., 2005).”
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ42 in humans (2006, methodology): “The validity of Logan analysis of PIB data and its comparison with other methods of pharmacokinetic analysis have been reported.(14,15) PIB binding potential (binding potential distribution volume 1) in each ROI was then calculated for each subject.”